The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Although the conventional activities of p53 such as cell cycle arrest, senescence, and
apoptosis are well accepted as the major checkpoints in stress responses, accumulating …

Ferroptosis, a newly discovered iron-dependent cell death pathway, is characterized by lipid
peroxidation and GSH depletion mediated by iron metabolism and is morphologically …

Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Objectives Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC
activation and ECM accumulation. The underlying mechanism remains unclear. Ferroptosis …

Ferroptosis is a recently identified non-apoptotic form of cell death characterized by iron-
dependent lipid peroxidation. However, the underlying exact mechanisms remain poorly …

Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …