Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Cancer proliferation and progression involves altered metabolic pathways as a result of
continuous demand for energy and nutrients. In the last years, cell cycle regulators have …

The dependency of cancer cells on glutamine may be exploited therapeutically as a new
strategy for treating cancers that lack druggable driver genes. Here we found that human …

The study of cancer metabolism has evolved vastly beyond the remit of tumour proliferation
and survival with the identification of the role of 'oncometabolites' in tumorigenesis. Simply …

The successful treatment of human cancers by immunotherapy has been made possible by
breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD …

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and
30% of patients with CRC experience metastasis. Patients with metastatic colorectal cancer …

Tumour cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of
rapid cell growth. However, glutamine dependence can be highly variable between in vitro …

Glioblastoma (GBM) is the most aggressive primary brain tumor, with a median survival at
diagnosis of 16–20 months. Metabolism represents a new attractive therapeutic target; …

A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione
(GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed …

Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies
resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of …