Background The early diagnosis of tuberculosis using novel non-sputum-based biomarkers
is of high priority in the End TB strategy. MicroRNAs (miRNAs) are significant regulators of …

Background Diagnosis of tuberculosis (TB) is still difficult. The purpose of our study was to
evaluate the diagnostic accuracy of Mycobacterium tuberculosis cell-free DNA (cfDNA) for …

There remains a pressing need for biomarkers that can predict who will progress to active
tuberculosis (TB) after exposure to Mycobacterium tuberculosis (MTB) bacterium. By …

Novel accurate tests are needed that identify individuals infected with Mycobacterium
tuberculosis who have incipient disease and are likely to develop clinical tuberculosis (TB) …

Efforts to reduce the global TB burden are hindered by the lack of simple, reliable non-
sputum based diagnostics. To date studies investigating the biomarker potential of …

Highlights•Current intervention measures for tuberculosis (TB) treatment are far from
satisfactory.•Mycobacteria alter the host microRNA (miRNA) expression profile to their …

Background Recent studies have revealed the involvement of circular RNAs (circRNAs) in
the control and elimination of invading Mycobacterium tuberculosis (Mtb) by macrophages …

It has long been understood that tuberculosis (TB) host defense depends on cellular
immunity, including primary containment by macrophages and secondary containment by …

Despite more than a decade of active study, tuberculosis (TB) remains a serious health
concern across the world, and it is still the biggest cause of mortality in the human …

Background The positive predictive value of tuberculin skin test and current generation
interferon gamma release assays are very low leading to high numbers needed to treat …