Designing tuberculosis vaccine efficacy trials–lessons from recent studies

AM Ginsberg - Expert Review of Vaccines, 2019 - Taylor & Francis
Introduction: Tuberculosis (TB) is the leading infectious killer globally and new TB vaccines
will be crucial to ending the epidemic. Since the introduction in 1921 of the only currently …

Significance of extracellular vesicles in orchestration of immune responses in Mycobacterium tuberculosis infection

SD Alipoor, D Elieh-Ali-Komi - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
Mycobacterium tuberculosis (M. tb), the causative agent of Tuberculosis, is an intracellular
bacterium well known for its ability to subvert host energy and metabolic pathways to …

Advances in computational frameworks in the fight against TB: The way forward

A Naidu, SS Nayak, S Lulu S… - Frontiers in …, 2023 - frontiersin.org
Around 1.6 million people lost their life to Tuberculosis in 2021 according to WHO estimates.
Although an intensive treatment plan exists against the causal agent, Mycobacterium …

Biomarkers for detecting resilience against mycobacterial disease in animals

K Wright, K Plain, A Purdie, BM Saunders… - Infection and …, 2019 - Am Soc Microbiol
Paratuberculosis and bovine tuberculosis are two mycobacterial diseases of ruminants
which have a considerable impact on livestock health, welfare, and production. These are …

A systematic review and meta-analysis of circulating serum and plasma microRNAs in TB diagnosis

H Gunasekaran, P Sampath, K Thiruvengadam… - BMC Infectious …, 2024 - Springer
Background Tuberculosis (TB) ranks as the second leading cause of death globally among
all infectious diseases. This problem is likely due to the lack of biomarkers to differentiate the …

Can miRNA Indicate Risk of Illness after Continuous Exposure to M. tuberculosis?

CA Silva, A Ribeiro-dos-Santos, WG Gonçalves… - International journal of …, 2021 - mdpi.com
Simple Summary Tuberculosis is the leading cause of mortality from a single infectious
agent and is among the top 10 causes of death worldwide. Despite that, few studies focus on …

The mycobacterial HBHA protein: a promising biomarker for tuberculosis

F De Maio, F Squeglia, D Goletti… - Current Medicinal …, 2019 - ingentaconnect.com
A major goal in tuberculosis (TB) research is the identification, among the subjects infected
with Mycobacterium tuberculosis (Mtb), of those with active TB, or at higher risk of …

Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling

T Carney, JA Rooney, N Niemand, B Myers, D Theron… - Plos one, 2022 - journals.plos.org
People who use illicit drugs (PWUDs) have been identified as a key at-risk group for
tuberculosis (TB). Examination of illicit drug use networks has potential to assess the risk of …

Systematic evaluation, verification and comparison of tuberculosis‐related non‐coding RNA diagnostic panels

M Lyu, Y Cheng, J Zhou, W Chong… - Journal of Cellular …, 2021 - Wiley Online Library
We systematically summarized tuberculosis (TB)‐related non‐coding RNA (ncRNA)
diagnostic panels, validated and compared panel performance. We searched TB‐related …

Paradigm changing evidence that alter tuberculosis perception and detection: Focus on latency

J Sousa, M Saraiva - Infection, Genetics and Evolution, 2019 - Elsevier
Tuberculosis remains a devastating disease to Mankind, ranking as the ninth cause of death
worldwide. Eliminating tuberculosis as proven much more difficult than once anticipated. In …