The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

Matrix metalloproteinases (MMPs) are members of the metzincin group of proteases which
share the conserved zinc-binding motif in their catalytic active site. It was originally thought …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …

Secreted and membrane tethered matrix metalloproteinases (MMPs) are key homeostatic
proteases regulating the extracellular signaling and structural matrix environment of cells …

Bone-forming cells originate from distinct embryological layers, mesoderm (axial and
appendicular bones) and ectoderm (precursor of neural crest cells, which mainly form facial …

Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-
dependent proteins, which are thought to play a central role in the breakdown of …

Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …

Objective—Vascular calcification significantly increases cardiovascular morbidity and
mortality. We recently reported that the deficiency of cartilage oligomeric matrix protein …

Colorectal cancer is one of the most common cancers worldwide, and it is also one of the
major causes of mortality from cancer. Chemotherapy drugs are generally limited due to …