Human evolution has shaped gender differences between males and females. Over the
years, scientific studies have proposed that epigenetic modifications significantly influence …

In the last decade epigenetics has come to the fore as a discipline which is central to
biogerontology. Age associated epigenetic changes are routinely linked with pathologies …

Life course epidemiology emerged in the 1990s as a response to the growing rift between
differing theoretical models of disease etiology. As such it attempted to synthesize existing …

Purpose Left-right asymmetry, an important feature of brain development, has been
implicated in neurodegenerative diseases, although it's less discussed in typical Alzheimer's …

Alzheimer's disease (AD) is the most common type of neurodegenerative disease and its
pathogenesis is still unclear. Genetic factors are thought to account for a large proportion of …

Spinal stenosis is a common degenerative spine disorder in the aged population and the
spinal ligament aging is a main contributor to this chronic disease. However, the underlying …

Episignatures are popular tools for the diagnosis of rare neurodevelopmental disorders.
They are commonly based on a set of differentially methylated CpGs used in combination …

Anti-ageing biology and medicine programmes are a focus of genetics, molecular biology,
immunology, endocrinology, nutrition, and therapy. This paper discusses metabolic …

DNA methylation is widely recognized to play a role in intracranial aneurysm (IA)
pathogenesis. We investigated the levels of methylation of vestigial-like 3 (VGLL3) in IA and …

Aberrantly methylated circulating DNA (cirDNA) has proven to be a good cancer marker, but
its detection is limited by low concentrations, fragmentation, and insufficiency. Since the …