Sex-specific DNA methylation: impact on human health and development
Human evolution has shaped gender differences between males and females. Over the
years, scientific studies have proposed that epigenetic modifications significantly influence …
years, scientific studies have proposed that epigenetic modifications significantly influence …
[HTML][HTML] An evolutionary perspective of lifespan and epigenetic inheritance
MT Mc Auley - Experimental Gerontology, 2023 - Elsevier
In the last decade epigenetics has come to the fore as a discipline which is central to
biogerontology. Age associated epigenetic changes are routinely linked with pathologies …
biogerontology. Age associated epigenetic changes are routinely linked with pathologies …
Life course epidemiology
Life course epidemiology emerged in the 1990s as a response to the growing rift between
differing theoretical models of disease etiology. As such it attempted to synthesize existing …
differing theoretical models of disease etiology. As such it attempted to synthesize existing …
The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer's disease
J Lu, Z Zhang, P Wu, X Liang, H Zhang, J Hong… - NeuroImage: Clinical, 2023 - Elsevier
Purpose Left-right asymmetry, an important feature of brain development, has been
implicated in neurodegenerative diseases, although it's less discussed in typical Alzheimer's …
implicated in neurodegenerative diseases, although it's less discussed in typical Alzheimer's …
ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer's Disease
X Qian, S Chen, X Liu, H Tang - Molecular Neurobiology, 2023 - Springer
Alzheimer's disease (AD) is the most common type of neurodegenerative disease and its
pathogenesis is still unclear. Genetic factors are thought to account for a large proportion of …
pathogenesis is still unclear. Genetic factors are thought to account for a large proportion of …
[HTML][HTML] Epigenetic modifications in spinal ligament aging
Q Xiang, Y Zhao, J Lin, S Jiang, W Li - Ageing Research Reviews, 2022 - Elsevier
Spinal stenosis is a common degenerative spine disorder in the aged population and the
spinal ligament aging is a main contributor to this chronic disease. However, the underlying …
spinal ligament aging is a main contributor to this chronic disease. However, the underlying …
Comprehensive evaluation of the implementation of episignatures for diagnosis of neurodevelopmental disorders (NDDs)
E Giuili, R Grolaux, CZNM Macedo, L Desmyter… - Human genetics, 2023 - Springer
Episignatures are popular tools for the diagnosis of rare neurodevelopmental disorders.
They are commonly based on a set of differentially methylated CpGs used in combination …
They are commonly based on a set of differentially methylated CpGs used in combination …
Tricarboxylic acid cycle intermediates and individual ageing
N Kurhaluk - Biomolecules, 2024 - mdpi.com
Anti-ageing biology and medicine programmes are a focus of genetics, molecular biology,
immunology, endocrinology, nutrition, and therapy. This paper discusses metabolic …
immunology, endocrinology, nutrition, and therapy. This paper discusses metabolic …
Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations
Y Liu, S Chen, E Zhang, Y Xu, X Deng, Z Hu… - Bioscience …, 2024 - portlandpress.com
DNA methylation is widely recognized to play a role in intracranial aneurysm (IA)
pathogenesis. We investigated the levels of methylation of vestigial-like 3 (VGLL3) in IA and …
pathogenesis. We investigated the levels of methylation of vestigial-like 3 (VGLL3) in IA and …
Size and methylation index of cell-free and cell-surface-bound DNA in blood of breast cancer patients in the contest of liquid biopsy
S Tamkovich, A Tupikin, A Kozyakov… - International Journal of …, 2022 - mdpi.com
Aberrantly methylated circulating DNA (cirDNA) has proven to be a good cancer marker, but
its detection is limited by low concentrations, fragmentation, and insufficiency. Since the …
its detection is limited by low concentrations, fragmentation, and insufficiency. Since the …