Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Drug resistance in Plasmodium
K Haldar, S Bhattacharjee, I Safeukui - Nature Reviews Microbiology, 2018 - nature.com
A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …
administration of effective antimalarials against Plasmodium falciparum, in particular …
COVID-19: attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism
L Wenzhong, L Hualan - 2020 - chemrxiv.org
The novel coronavirus pneumonia is a contagious acute respiratory disease caused by the
SARS-COV-2 coronavirus. The pathogenic mechanism of the novel coronavirus is unknown …
SARS-COV-2 coronavirus. The pathogenic mechanism of the novel coronavirus is unknown …
[HTML][HTML] Functional profiling of a Plasmodium genome reveals an abundance of essential genes
The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …
development through the identification of essential genes and pathways, we have measured …
[HTML][HTML] Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
The mechanism of action of artemisinin and its derivatives, the most potent of the anti-
malarial drugs, is not completely understood. Here we present an unbiased chemical …
malarial drugs, is not completely understood. Here we present an unbiased chemical …
Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa
PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …
important infectious diseases in the world. Standard treatment for uncomplicated P …
[HTML][HTML] Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
The widely used antimalarial combination therapy dihydroartemisinin+ piperaquine (DHA+
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …
[HTML][HTML] Cytokines and chemokines in cerebral malaria pathogenesis
Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …
[HTML][HTML] Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies
(ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites …
(ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites …