Social anxiety disorder-associated gut microbiota increases social fear

NL Ritz, M Brocka, MI Butler… - Proceedings of the …, 2024 - National Acad Sciences
Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense
fear or anxiety in social situations and their avoidance. However, the underlying biology of …

Convergence of oxytocin and dopamine signaling in neuronal circuits: Insights into the neurobiology of social interactions across species

V Rappeneau, F Castillo-Díaz - Neuroscience & Biobehavioral Reviews, 2024 - Elsevier
Social behaviours are essential for animal survival, and the hypothalamic neuropeptide
oxytocin (OXT) critically impacts bonding, parenting, and decision-making. Dopamine (DA) …

[HTML][HTML] Dual oxytocin receptor-G protein signaling in the autoregulation of activities of oxytocin neurons

XY Liu, S Ling, Y Liu, S Jia, X Wang, T Li, D Li… - …, 2024 - karger.com
Oxytocin (OT), a hypothalamic nonaneuropeptide, can extensively modulate mental and
physical activities; however, the regulation of its secretion from hypothalamic OT neurons …

Impaired emotion recognition in Cntnap2-deficient mice is associated with hyper-synchronous prefrontal cortex neuronal activity

AN Mohapatra, R Jabarin, N Ray, S Netser… - Molecular …, 2024 - nature.com
Individuals diagnosed with autism spectrum disorder (ASD) show difficulty in recognizing
emotions in others, a process termed emotion recognition. While human fMRI studies linked …

Adolescent social isolation disrupts developmental tuning of neuropeptide circuits in the hypothalamus to amygdala regulating social and defensive behavior

H Arakawa, M Tokashiki, Y Higuchi, T Konno - Peptides, 2024 - Elsevier
Engaging in positive social (ie, prosocial) interactions during adolescence acts to modulate
neural circuits that determine adult adaptive behavior. While accumulating evidence …

Social interaction-induced fear memory reduction: exploring the influence of dopamine and oxytocin receptors on memory updating

AD Arellano Perez, AS Kautzmann… - Translational …, 2024 - nature.com
It has been well established that a consolidated memory can be updated during the plastic
state induced by reactivation. This updating process opens the possibility to modify …

Potential role of oxytocin in the regulation of memories and treatment of memory disorders

V Walia, P Wal, S Mishra, A Agrawal, S Kosey, AD Patil - Peptides, 2024 - Elsevier
Oxytocin (OXT) is an “affiliative” hormone or neurohormone or neuropeptide consists of nine
amino acids, synthesized in magnocellular neurons of paraventricular (PVN) and supraoptic …

Oxytocin Enhances Time-Dependent Responses in the Aggressive Zebrafish (Danio rerio)

MA Robea, G Oprea, G Plavan, MN Nicoara… - Brain Sciences, 2024 - mdpi.com
Autism spectrum disorder (ASD) has become one of the most well-known disorders
encountered since early childhood among people. Nowadays, the main concerns are its …

Differential Functions of Oxytocin Receptor-Expressing Neurons in the Ventromedial Hypothalamus in Social Stress Responses: Induction of Adaptive and …

N Nasanbuyan, M Yoshida, A Inutsuka… - Biological …, 2024 - Elsevier
Background The flexibility to adjust actions and attitudes in response to varying social
situations is a fundamental aspect of adaptive social behavior. Adaptive social behaviors …

Aberrant TSC-Rheb axis in Oxytocin receptor+ cells mediate stress-induced anxiety

O Tabaka, S Lawal, RDR Triana, M Hou, A Fraser… - bioRxiv, 2024 - biorxiv.org
Stress is a major risk for the onset of several maladaptive processes including pathological
anxiety, a diffuse state of heightened apprehension over anticipated threats. Pathological …