Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Tissue regeneration is not simply a local repair event occurring in isolation from the distant,
uninjured parts of the body. Rather, evidence indicates that regeneration is a whole-animal …

The epigenome coordinates spatial-temporal specific gene expression during development
and in adulthood, for the maintenance of homeostasis and upon tissue repair. The upheaval …

Highlights•Epigenetic transcriptional regulation allows for maintenance of stable expression
states.•Epigenetic regulation requires DNA methylation, lncRNAs or histone modifications.• …

Adaptation enables cells to change their behavior in response to transient stimuli. While
adaptive programs of immune cells have been widely described, it has recently emerged …

Historically believed to be a homogeneous cell type that is often overlooked, fibroblasts are
more and more understood to be heterogeneous in nature. Though the mechanisms behind …

Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring
clonal advantage as the initial event. However, despite pervasive somatic mutations and …

Efficient oral mucosal wound healing requires coordinated responses from epithelial
progenitor cells, yet their spatiotemporal recruitment and activation remain unclear. Using a …

Background Recessive dystrophic epidermolysis bullosa (RDEB) is a blistering disease
caused by mutations in the gene encoding type VII collagen (C7). RDEB is associated with …