Importance Negative symptoms have a detrimental impact on functional outcomes and
quality of life in people with schizophrenia, and few therapeutic options are considered …

Background Schizophrenia is a complex psychiatric disorder that includes positive and
negative symptoms but also debilitating cognitive deficits. Current pharmacological …

Genome-wide association studies (GWASs) are a valuable tool for understanding the
biology of complex human traits and diseases, but associated variants rarely point directly to …

Schizophrenia has been an evolutionary paradox: it has high heritability, but it is associated
with decreased reproductive success. The causal genetic variants underlying schizophrenia …

Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

Schizophrenia is a very complex syndrome involving widespread brain multi-
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …

A prominent neurotransmitter (NT), dopamine (DA), is a chemical messenger that transmits
signals between one neuron to the next to pass on a signal to and from the central nervous …

Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for
cognition. Studies in humans indicate that these interactions may resolve uncertainty in …

Schizophrenia is associated with increased levels of oxidative stress, as reflected by an
increase in the concentrations of damaging reactive species and a reduction in anti-oxidant …