Classification-based strategies to simplify complex traditional Chinese medicine (TCM) researches through liquid chromatography-mass spectrometry in the last …

YH Chen, JH Bi, M Xie, H Zhang, ZQ Shi, H Guo… - … of Chromatography A, 2021 - Elsevier
The difficulty of traditional Chinese medicine (TCM) researches lies in the complexity of
components, metabolites, and bioactivities. For a long time, there has been a lack of …

Identification of Antitumor Active Constituents in Polygonatum sibiricum Flower by UPLC-Q-TOF-MSE and Network Pharmacology

Z Huang, X Du, C Ma, R Zhang, W Gong, F Liu - ACS omega, 2020 - ACS Publications
We aimed to investigate the material basis and mechanisms underlying the antitumor activity
of Polygonatum sibiricum flower by ultra-performance liquid chromatography quadrupole …

Rapid identification of absorbed components and metabolites of Gandou decoction in rat plasma and liver by UPLC-Q-TOF-MSE

L Xu, Y Liu, H Wu, A Zhou - Journal of Chromatography B, 2020 - Elsevier
Gandou Decoction (GDD), a well-known traditional Chinese medicine prescription, has
been widely used for decades in clinical practice to treat Wilson's disease (WD) in China …

[HTML][HTML] An integrated strategy for comprehensive characterization of metabolites and metabolic profiles of bufadienolides from Venenum Bufonis in rats

WL Wei, HJ Li, WZ Yang, H Qu, ZW Li, CL Yao… - Journal of …, 2022 - Elsevier
Comprehensive characterization of metabolites and metabolic profiles in plasma has
considerable significance in determining the efficacy and safety of traditional Chinese …

UPLC-ESI-MRM/MS for absolute quantification and MS/MS structural elucidation of six specialized pyranonaphthoquinone metabolites from Ventilago harmandiana

S Limjiasahapong, K Kaewnarin, N Jariyasopit… - Frontiers in plant …, 2021 - frontiersin.org
Pyranonaphthoquinones (PNQs) are important structural scaffolds found in numerous
natural products. Research interest in these specialized metabolites lies in their natural …

Elucidation of the mechanisms and molecular targets of Run-zao-zhiyang Capsule for itch based on network pharmacology, molecular docking and in vitro experiment

J Wang, H Li, Z Yang, C Huang… - … Chemistry & High …, 2023 - ingentaconnect.com
Background: Traditional Chinese medicine formula (TCMF) Run-zao-zhi-yang capsule
(RZZY) is commonly used in treating itch in China. However, there are few studies on its …

Systematic Characterization of Active Antitumor Constituents from the Shaggy Bracket Medicinal Mushroom Inonotus hispidus (Agaricomycetes) by UPLC-Q-TOF/MS …

LF Zan, JC Xin, HY Guo, H Bao… - International Journal of …, 2023 - dl.begellhouse.com
Inonotus hispidus is a well-known medicinal fungus and has been used in the treatment of
cancer in China, but the material basis and potential mechanisms are still limited. The …

Systematic comparison of metabolic differences of Uncaria rhynchophylla in rat, mouse, dog, pig, monkey and human liver microsomes

HJ Li, WL Wei, ZW Li, CL Yao, MY Wang… - Analytical and …, 2020 - Springer
Metabolites have a close relationship with the efficacy and safety of herbal medicines.
However, ubiquitous matrix interferences, complex co-elution, and minor or trace amounts in …