Over the past several years, drug addiction has increasingly been accepted to be a disease
of the brain as opposed to simply being due to a lack of willpower or personality flaw …

Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust
protection against subsequent lethal injuries. Preconditioning has been observed in multiple …

Parkinson's disease is a progressive neurodegenerative disorder characterized by the
degeneration of midbrain nigral dopaminergic neurons. Although its etiology remains …

N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an
important role in learning and memory, and are critical for spatial memory. These receptors …

Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium
permeability that play important roles in many aspects of the biology of higher organisms …

In humans, heterogeneity in the decline of hippocampal-dependent episodic memory is
observed during aging. Rodents have been employed as models of age-related cognitive …

Object location task (OLT) has been used as a model of hippocampal-dependent memory.
Despite this application, there is neither a consistent pharmacological validation of NMDA …

Increasing evidence supports a rapid antidepressant and antisuicidal effect of a single
subanesthetic dose of ketamine infusion for treatment-resistant depression (TRD) …

The contribution of the NMDA receptors (NMDARs) to synaptic plasticity declines during
aging, and the decline is thought to contribute to memory deficits. Here, we demonstrate that …