p21 cip1/waf1 mediates various biological activities by sensing and responding to multiple
stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor …

Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …

Background: Current differentiation protocols to produce cardiomyocytes from human
induced pluripotent stem cells (iPSCs) are capable of generating highly pure cardiomyocyte …

Nucleotide synthesis is a metabolically demanding process essential for DNA replication
and other processes in the cell. Several anticancer drugs that inhibit nucleotide metabolism …

There are few reports describing the role of p53-dependent gene repression in apoptotic cell
death. To identify such apoptosis-associated p53 target genes, we used the pro-oxidant …

Abstract Objective Cannabinoids, including delta-8-and delta-9-tetrahydrocannabinol (THC)
have a palliative care impact and may therefore be beneficial against cancer. The aim of this …

Together with cities in higher-income nations, it is anticipated that the real global ozone is
rising in densely populated areas of Asia and Africa. This review aims to discuss the …

Ionizing radiation triggers diverse responses in human cells encompassing apoptosis,
necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (eg …

Cyanobacteria are ubiquitous phototrophic bacteria that inhabit diverse environments
across the planet. Seasonally, they dominate many eutrophic lakes impacted by excess …

p21 Waf1/Cip1/Sdi1 is a cyclin-dependent kinase inhibitor that mediates cell cycle arrest.
Prolonged p21 up-regulation induces a senescent phenotype in normal and cancer cells …