A dynamic DNA tetrahedron framework for active targeting

T Tian, T Zhang, S Shi, Y Gao, X Cai, Y Lin - Nature Protocols, 2023 - nature.com
An active targeting strategy-enabled DNA tetrahedron delivery vehicle could facilitate stable
drug encapsulation and stimuli-responsive on-demand release, building a universal …

Bioinspired gradient scaffolds for osteochondral tissue engineering

Y Peng, Y Zhuang, Y Liu, H Le, D Li, M Zhang… - …, 2023 - Wiley Online Library
Repairing articular osteochondral defects present considerable challenges in self‐repair
due to the complex tissue structure and low proliferation of chondrocytes. Conventional …

Typhaneoside-tetrahedral framework nucleic acids system: mitochondrial recovery and antioxidation for acute kidney injury treatment

R Yan, W Cui, W Ma, J Li, Z Liu, Y Lin - ACS nano, 2023 - ACS Publications
Acute kidney injury (AKI) is not only a worldwide problem with a cruel hospital mortality rate
but also an independent risk factor for chronic kidney disease and a promoting factor for its …

Functionalized DNA nanomaterials targeting toll‐like receptor 4 prevent bisphosphonate‐related osteonecrosis of the jaw via regulating mitochondrial homeostasis in …

T Zhang, H Ma, X Zhang, S Shi… - Advanced Functional …, 2023 - Wiley Online Library
Imbalance of macrophage polarization characterized by an increase in the percentage of
pro‐inflammatory M1 macrophages and a decrease in anti‐inflammatory M2 macrophages …

Amelioration of osteoarthritis via tetrahedral framework nucleic acids delivering microrna‐124 for cartilage regeneration

S Shi, T Chen, W Lu, Y Chen, D Xiao… - Advanced Functional …, 2023 - Wiley Online Library
MicroRNAs (miRNAs) regulate several physiological and pathological processes involved in
various diseases, including osteoarthritis (OA). OA is the most common global …

[HTML][HTML] A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

Y Li, Z Cai, W Ma, L Bai, E Luo, Y Lin - Bone Research, 2024 - nature.com
Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the
bone health of patients with diabetes; however, currently, there are no effective treatment …

[HTML][HTML] Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Multifunctional MXene-based bioactive materials for integrated regeneration therapy

J Ma, L Zhang, B Lei - ACS nano, 2023 - ACS Publications
The reconstruction engineering of tissue defects accompanied by major diseases including
cancer, infection, and inflammation is one of the important challenges in clinical medicine …

A transdermal drug delivery system based on nucleic acid nanomaterials for skin photodamage treatment

Y Xie, J He, S Li, X Chen, T Zhang… - Advanced Functional …, 2023 - Wiley Online Library
Skin photodamage, which is induced by ultraviolet (UV) radiation, is a prevalent cause of
skin damage. In this study, a transdermal drug delivery system is developed for the topical …

Suppression of lipopolysaccharide‐induced sepsis by tetrahedral framework nucleic acid loaded with quercetin

Z Liu, X Chen, W Ma, Y Gao, Y Yao, J Li… - Advanced Functional …, 2022 - Wiley Online Library
Sepsis has affected millions of people worldwide with high mortality rate and lack of effective
strategies. Previous studies have reported that quercetin (Que) can attenuate …