Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease

TJ Tracey, FJ Steyn, EJ Wolvetang… - Frontiers in molecular …, 2018 - frontiersin.org
Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

Fatty acid transport and signaling: mechanisms and physiological implications

D Samovski, M Jacome-Sosa… - Annual review of …, 2023 - annualreviews.org
Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel
source and also serve as metabolic regulators through FA signaling mediated by membrane …

[HTML][HTML] CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

JW Hao, J Wang, H Guo, YY Zhao, HH Sun… - Nature …, 2020 - nature.com
Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains
unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in …

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

VS Peche, TA Pietka, M Jacome-Sosa… - Nature …, 2023 - nature.com
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

Advances in fatty acids nutrition in dairy cows: from gut to cells and effects on performance

M Bionaz, E Vargas-Bello-Pérez, S Busato - Journal of Animal Science …, 2020 - Springer
High producing dairy cows generally receive in the diet up to 5–6% of fat. This is a relatively
low amount of fat in the diet compared to diets in monogastrics; however, dietary fat is …

The cell biology of fat expansion

JM Rutkowski, JH Stern, PE Scherer - Journal of Cell Biology, 2015 - rupress.org
Adipose tissue is a complex, multicellular organ that profoundly influences the function of
nearly all other organ systems through its diverse metabolite and adipokine secretome …

CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

Regulation of adipocyte lipolysis

G Frühbeck, L Méndez-Giménez… - Nutrition research …, 2014 - cambridge.org
In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease

JFC Glatz, JJFP Luiken, A Bonen - Physiological reviews, 2010 - journals.physiology.org
Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Taste of fat: a sixth taste modality?

P Besnard, P Passilly-Degrace… - Physiological …, 2016 - journals.physiology.org
An attraction for palatable foods rich in lipids is shared by rodents and humans. Over the last
decade, the mechanisms responsible for this specific eating behavior have been actively …