Regulatory T cells in multiple sclerosis and myasthenia gravis

KM Danikowski, S Jayaraman… - Journal of …, 2017 - Springer
Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system
primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically …

[HTML][HTML] Regulatory T cell function in autoimmune disease

A Rajendiran, K Tenbrock - Journal of translational autoimmunity, 2021 - Elsevier
Autoimmune diseases are characterized by a failure of tolerance to own body components
resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review …

[HTML][HTML] Imbalance between T helper 17 and regulatory T cell subsets plays a significant role in the pathogenesis of systemic sclerosis

C Mo, Z Zeng, Q Deng, Y Ding, R Xiao - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Systemic sclerosis (SSc) is a rare autoimmune disease that is characterized by fibrosis,
inflammation, and vasculopathy of the skin and internal organs. The etiopathogenesis of …

Epigenetic variability of CD4+ CD25+ Tregs contributes to the pathogenesis of autoimmune diseases

Y Shu, Q Hu, H Long, C Chang, Q Lu… - Clinical reviews in allergy & …, 2017 - Springer
Autoimmune diseases are characterized by aberrant immune responses against healthy
cells and tissues. However, the exact mechanisms underlying the development of these …

[HTML][HTML] CD4+ CD25hiFoxp3+ cells exacerbate bleomycin-induced pulmonary fibrosis

SZ Birjandi, V Palchevskiy, YY Xue, S Nunez… - The American journal of …, 2016 - Elsevier
Idiopathic pulmonary fibrosis is a fatal lung disease with a median survival of 2 to 5 years. A
decade of studies has downplayed inflammation contributing to its pathogenesis. However …

Regulatory T cell responses to high-dose methylprednisolone in active systemic lupus erythematosus

A Mathian, R Jouenne, D Chader, F Cohen-Aubart… - PloS one, 2015 - journals.plos.org
Background/Purpose A slight increase in the proportion of circulating regulatory T (Treg)
cells has been reported in systemic lupus erythematosus (SLE) patients taking oral …

Immunosuppressive effect of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via regulating the differentiation of CD4+ T cell subsets in …

L Bai, H Li, J Li, J Song, Y Zhou, B Liu, R Lu… - International …, 2019 - Elsevier
Immunoglobulin A nephropathy (IgAN) is an autoimmune kidney disease with complex
pathogenesis leading to end-stage renal damage. The crucial pathological characteristic in …

Increased Levels of STAT1 Protein in Blood CD4 T Cells from Systemic Lupus Erythematosus Patients Are Associated with Perturbed Homeostasis of Activated CD45RA-FOXP3 …

A Goropevšek, M Gorenjak, S Gradišnik… - Journal of Interferon & …, 2017 - liebertpub.com
In murine systemic lupus erythematosus (SLE), aberrant regulation of interferon (IFN)-alpha-
STAT1 signaling and perturbed homeostasis of CD4+ FOXP3+ regulatory T cells (Tregs) …

Analysis of FOXP3+ regulatory T cell subpopulations in peripheral blood and tissue of patients with systemic lupus erythematosus

A Schmidt, CC Rieger, RK Venigalla, S Éliás… - Immunologic …, 2017 - Springer
Regulatory T cells (Tregs) are critical mediators of immune tolerance, yet their involvement
in the autoimmune disease systemic lupus erythematosus (SLE) is incompletely understood …

Short-term prognostic effects of circulating regulatory T-Cell suppressive function and vascular endothelial growth factor level in patients with non-small cell lung …

Y Liu, M Lao, J Chen, M Lu, S Luo, Q Ou, Z Luo… - Sleep medicine, 2020 - Elsevier
Objective To determine if suppressive function of regulatory T-cells (Tregs) and vascular
endothelial cell growth factor (VEGF) levels are closely associated with prognosis of patients …