[HTML][HTML] The effect of erythropoietin and its derivatives on ischemic stroke therapy: a comprehensive review

Y Ma, Z Zhou, GY Yang, J Ding, X Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
Numerous studies explored the therapeutic effects of erythropoietin (EPO) on
neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of …

[HTML][HTML] New insights into Sirt1: potential therapeutic targets for the treatment of cerebral ischemic stroke

H Tang, J Wen, T Qin, Y Chen, J Huang… - Frontiers in Cellular …, 2023 - frontiersin.org
Ischemic stroke is one of the main causes of mortality and disability worldwide. However, the
majority of patients are currently unable to benefit from intravenous thrombolysis or …

Activation of RKIP binding ASC attenuates neuronal pyroptosis and brain injury via caspase-1/GSDMD signaling pathway after intracerebral hemorrhage in mice

L Gu, M Sun, R Li, Y Tao, X Luo, J Xu, X Wu… - Translational Stroke …, 2022 - Springer
Pyroptosis has been proven to be responsible for secondary brain injury after intracerebral
hemorrhage (ICH). A recent study reported that Raf kinase inhibitor protein (RKIP) inhibited …

[HTML][HTML] Takinib inhibits microglial M1 polarization and oxidative damage after subarachnoid hemorrhage by targeting TAK1-dependent NLRP3 inflammasome …

W Wang, C Pang, J Zhang, L Peng, X Zhang… - Frontiers in …, 2023 - frontiersin.org
Transforming growth factor-β-activated kinase 1 (TAK1) positively regulates oxidative stress
and inflammation in different diseases. Takinib, a novel and specific TAK1 inhibitor, has …

[HTML][HTML] Glial cells and brain diseases: inflammasomes as relevant pathological entities

E Mata-Martínez, M Díaz-Muñoz… - Frontiers in cellular …, 2022 - frontiersin.org
Inflammation mediated by the innate immune system is a physiopathological response to
diverse detrimental circumstances such as microbe infections or tissular damage. The …

[HTML][HTML] Beauty and the beast: host microRNA-155 versus SARS-CoV-2

KI Papadopoulos, A Papadopoulou, TC Aw - Human Cell, 2023 - Springer
Severe acute respiratory coronavirus 2 (SARS-CoV-2) infection in the young and healthy
usually results in an asymptomatic or mild viral syndrome, possibly through an erythropoietin …

AIM2 inflammasome: A potential therapeutic target in ischemic stroke

R Fu, L Zhao, Y Guo, X Qin, W Xu, X Cheng, Y Zhang… - Clinical …, 2023 - Elsevier
Ischemic stroke (IS) is a significant global public health issue with a high incidence,
disability, and mortality rate. A robust inflammatory cascade with complex and wide-ranging …

Protection of a novel velvet antler polypeptide PNP1 against cerebral ischemia-reperfusion injury

H Pei, R Du, Z He, Y Yang, S Wu, W Li, J Sheng… - International Journal of …, 2023 - Elsevier
Aim We isolated a novel polypeptide PNP1 from velvet antler and investigated the role of
PNP1 in ischemia reperfusion and its associated mechanism. Methods We built the …

Regulated necrosis pathways: a potential target for ischemic stroke

K Ren, J Pei, Y Guo, Y Jiao, H Xing, Y Xie… - Burns & …, 2023 - academic.oup.com
Globally, ischemic stroke causes millions of deaths per year. The outcomes of ischemic
stroke are largely determined by the amount of ischemia-related and reperfusion-related …

[HTML][HTML] Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke

N Wang, F Chu, L Zhang, C Fei, C Yu, S Xue… - Frontiers in …, 2022 - frontiersin.org
Taohong siwu decoction (THSWD) has been shown to have a therapeutic effect on ischemic
strokes (IS). However, it is not clear to us whether THSWD reduces deoxyribonucleic acid …