Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications

MO Goodarzi - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

Diabetes, obesity, and cancer—pathophysiology and clinical implications

IC Lega, LL Lipscombe - Endocrine reviews, 2020 - academic.oup.com
Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …

Adiposity and cancer at major anatomical sites: umbrella review of the literature

M Kyrgiou, I Kalliala, G Markozannes, MJ Gunter… - Bmj, 2017 - bmj.com
Objective To evaluate the strength and validity of the evidence for the association between
adiposity and risk of developing or dying from cancer. Design Umbrella review of systematic …

Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer

C Gao, CJ Patel, K Michailidou, U Peters… - International journal …, 2016 - academic.oup.com
Background: Adiposity traits have been associated with risk of many cancers in
observational studies, but whether these associations are causal is unclear. Mendelian …

[PDF][PDF] Weight gain and impaired glucose metabolism in women are predicted by inefficient subcutaneous fat cell lipolysis

P Arner, DP Andersson, J Bäckdahl, I Dahlman… - Cell metabolism, 2018 - cell.com
Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure.
Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if …

Obesity genes and weight loss during lifestyle intervention in children with obesity

M Heitkamp, M Siegrist, S Molnos, S Brandmaier… - JAMA …, 2021 - jamanetwork.com
Importance Genome-wide association studies have identified genetic loci influencing
obesity risk in children. However, the importance of these loci in the associations with weight …

Precision medicine of obesity as an integral part of type 2 diabetes management–past, present, and future

L Szczerbinski, JC Florez - The Lancet Diabetes & Endocrinology, 2023 - thelancet.com
Obesity is a complex and heterogeneous condition that leads to various metabolic
complications, including type 2 diabetes. Unfortunately, for some, treatment options to date …

Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization

T Skaaby, AE Taylor, BH Thuesen, RK Jacobsen… - Allergy, 2018 - Wiley Online Library
Background Observational studies have shown that body mass index (BMI) is positively
associated with asthma. However, observational data are prone to confounding and reverse …

Genetic predisposition to obesity, restrained eating and changes in body weight: a population-based prospective study

H Konttinen, C Llewellyn, K Silventoinen… - International Journal of …, 2018 - nature.com
Objectives: There is no consensus on whether cognitive control over food intake (that is,
restrained eating) is helpful, merely ineffective or actually harmful in weight management …

[HTML][HTML] Advances in exercise, fitness, and performance genomics in 2014

RJF Loos, JM Hagberg, L Pérusse… - Medicine and science …, 2015 - ncbi.nlm.nih.gov
This is the annual review of the exercise genomics literature in which we report on the
highest quality papers published in 2014. We identified a number of noteworthy papers …