Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications
MO Goodarzi - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
Diabetes, obesity, and cancer—pathophysiology and clinical implications
IC Lega, LL Lipscombe - Endocrine reviews, 2020 - academic.oup.com
Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …
Adiposity and cancer at major anatomical sites: umbrella review of the literature
Objective To evaluate the strength and validity of the evidence for the association between
adiposity and risk of developing or dying from cancer. Design Umbrella review of systematic …
adiposity and risk of developing or dying from cancer. Design Umbrella review of systematic …
Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer
Background: Adiposity traits have been associated with risk of many cancers in
observational studies, but whether these associations are causal is unclear. Mendelian …
observational studies, but whether these associations are causal is unclear. Mendelian …
[PDF][PDF] Weight gain and impaired glucose metabolism in women are predicted by inefficient subcutaneous fat cell lipolysis
P Arner, DP Andersson, J Bäckdahl, I Dahlman… - Cell metabolism, 2018 - cell.com
Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure.
Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if …
Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if …
Obesity genes and weight loss during lifestyle intervention in children with obesity
M Heitkamp, M Siegrist, S Molnos, S Brandmaier… - JAMA …, 2021 - jamanetwork.com
Importance Genome-wide association studies have identified genetic loci influencing
obesity risk in children. However, the importance of these loci in the associations with weight …
obesity risk in children. However, the importance of these loci in the associations with weight …
Precision medicine of obesity as an integral part of type 2 diabetes management–past, present, and future
L Szczerbinski, JC Florez - The Lancet Diabetes & Endocrinology, 2023 - thelancet.com
Obesity is a complex and heterogeneous condition that leads to various metabolic
complications, including type 2 diabetes. Unfortunately, for some, treatment options to date …
complications, including type 2 diabetes. Unfortunately, for some, treatment options to date …
Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization
Background Observational studies have shown that body mass index (BMI) is positively
associated with asthma. However, observational data are prone to confounding and reverse …
associated with asthma. However, observational data are prone to confounding and reverse …
Genetic predisposition to obesity, restrained eating and changes in body weight: a population-based prospective study
H Konttinen, C Llewellyn, K Silventoinen… - International Journal of …, 2018 - nature.com
Objectives: There is no consensus on whether cognitive control over food intake (that is,
restrained eating) is helpful, merely ineffective or actually harmful in weight management …
restrained eating) is helpful, merely ineffective or actually harmful in weight management …
[HTML][HTML] Advances in exercise, fitness, and performance genomics in 2014
This is the annual review of the exercise genomics literature in which we report on the
highest quality papers published in 2014. We identified a number of noteworthy papers …
highest quality papers published in 2014. We identified a number of noteworthy papers …