Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …

Bioprospecting is the exploration, extraction and screening of biological material and
sometimes indigenous knowledge to discover and develop new drugs and other products …

Objectives The discovery and development of TB drugs has met limited success, with two
new drugs approved over the last 40 years. Part of the difficulty resides in the lack of well …

Objective: The need of today's research is to develop successful and reliable diabetic animal
models for understanding the disease susceptibility and pathogenesis. Enormous success …

Drug susceptibility testing of Mycobacterium tuberculosis in the diagnostic laboratory
classifies clinical isolates as either drug-'resistant'or drug-'susceptible', on the basis of their …

Introduction: Tuberculosis remains a global health problem and pharmacokinetic variability
has been postulated as one of the causes of treatment failure and acquired drug resistance …

There has been an increased interest in pharmacokinetics and pharmacodynamics (PKPD)
of anti-tuberculosis drugs. A better understanding of the relationship between drug …

Highlights•In vitro PK/PD models are less costly and resource-intensive and permit
investigations of considerable duration which may not be feasible in animals.•Mouse thigh …

Test compounds used on in vitro model systems are conventionally delivered to cell culture
wells as fixed concentration bolus doses; however, this poorly replicates the …

We present a microfluidic device to expose cancer cells to a dynamic, in vivo-like
concentration profile of a drug, and quantify efficacy on-chip. About 30% of cancer patients …