Spectinamides are novel amide derivatives of the antibiotic spectinomycin that have
emerged as a new class of agents to treat tuberculosis. These agents showed potent in vitro …

Healthcare-associated infections affect 4 million patients annually in the EU and result in an
estimated 37,000 deaths per year. Of particular concern are the rapidly increasing …

Background Ertapenem is a broad spectrum carbapenem antibiotic and is being explored
against Mycobacterium tuberculosis. Carbapenems have anti-bacterial activity when the …

Proefschrift MA Zuur compleet v5.indd Page 1 University of Groningen Pharmacological
approaches to optimize TB treatment Zuur, Marlies IMPORTANT NOTE: You are advised to …

For a patient with metastatic colorectal cancer, there are limited clinical options aside from
chemotherapy. Unfortunately, the development of new chemotherapies is a long and costly …

The protracted duration of standard tuberculosis (TB) therapy suggests the inadequacy of
current first line TB drugs to eliminate the causative agent Mycobacterium tuberculosis (Mtb) …

Mycobacterium tuberculosis (Mtb), the causative pathogen for Tuberculosis (TB) disease, is
estimated to infect one third of the world's population and is the leading killer of an infectious …

Studies in the late 1990s indicated that poor PK and toxicity were the common causes of
many costly late-stage failures in drug development. In light of these situations, a battery of …

In an effort to combat the global Tuberculosis pandemic, Dr. Richard E. Lee and his group at
St. Jude Children's Research Hospital designed a novel series of anti-tuberculosis agents …

[eng] Prosthetic joint infections (PJI) are defined as difficult-to-treat, mainly due to the
presence of bacterial biofilm and other bacterial adaptive forms. An aggressive treatment …