[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
UM Zanger, M Schwab - Pharmacology & therapeutics, 2013 - Elsevier
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Let's talk about sex: Differences in drug therapy in males and females
Abstract Professor Henry Higgins in My Fair Lady said,'Why can'ta woman be more like a
man?'Perhaps unintended, such narration extends to the reality of current drug …
man?'Perhaps unintended, such narration extends to the reality of current drug …
Sex differences in pharmacokinetics predict adverse drug reactions in women
I Zucker, BJ Prendergast - Biology of sex differences, 2020 - Springer
Background Women experience adverse drug reactions, ADRs, nearly twice as often as
men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood …
men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood …
Diversity in clinical and biomedical research: a promise yet to be fulfilled
Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled | PLOS Medicine
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Skip to main content Advertisement PLOS Medicine Browse Current Issue Journal Archive …
Sex bias in neuroscience and biomedical research
Female mammals have long been neglected in biomedical research. The NIH mandated
enrollment of women in human clinical trials in 1993, but no similar initiatives exist to foster …
enrollment of women in human clinical trials in 1993, but no similar initiatives exist to foster …
Gender differences in the effects of cardiovascular drugs
An initiation-promotion protocol was used to test the hypothesis that unleaded gasoline (UG)
vapor acts as a liver tumor promoter in female mice under exposure conditions in which UG …
vapor acts as a liver tumor promoter in female mice under exposure conditions in which UG …
Sex differences in pharmacokinetics and pharmacodynamics
OP Soldin, DR Mattison - Clinical pharmacokinetics, 2009 - Springer
Significant differences that exist between the sexes affect the prevalence, incidence and
severity of a broad range of diseases and conditions. Men and women also differ in their …
severity of a broad range of diseases and conditions. Men and women also differ in their …
The X-files in immunity: sex-based differences predispose immune responses
EN Fish - Nature Reviews Immunology, 2008 - nature.com
Despite accumulating evidence in support of sex-based differences in innate and adaptive
immune responses, in the susceptibility to infectious diseases and in the prevalence of …
immune responses, in the susceptibility to infectious diseases and in the prevalence of …
Gender-specific pathway differences in the human serum metabolome
J Krumsiek, K Mittelstrass, KT Do, F Stückler, J Ried… - Metabolomics, 2015 - Springer
The susceptibility for various diseases as well as the response to treatments differ
considerably between men and women. As a basis for a gender-specific personalized …
considerably between men and women. As a basis for a gender-specific personalized …
Sex differences in the expression of hepatic drug metabolizing enzymes
DJ Waxman, MG Holloway - Molecular pharmacology, 2009 - ASPET
Sex differences in pharmacokinetics and pharmacodynamics characterize many drugs and
contribute to individual differences in drug efficacy and toxicity. Sex-based differences in …
contribute to individual differences in drug efficacy and toxicity. Sex-based differences in …