The term frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders characterized mainly by atrophy of the frontal and anterior temporal lobes. Based …

Progressive neurocognitive dysfunction is the leading cause of a reduced quality of life in
patients with primary brain tumors. Understanding how the human brain responds to cancer …

Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of
frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic …

Cerebral adrenoleukodystrophy (cALD) is a rare neurodegenerative disease characterized
by inflammatory demyelination in the central nervous system. Another neurodegenerative …

C9orf72 genetic mutation is the most common genetic cause of ALS/FTD accompanied by
abnormal protein insufficiency. Induced pluripotent stem cell (iPSC)-derived two …

Frontal temporal dementia (FTD) is a neurological disorder known to have fewer therapeutic
options. So far, only a few biomarkers are available for FTD that can be used as potential …

Abstract Aims Frontotemporal Dementia (FTD) is caused by frontal-temporal lobar
degeneration (FTLD), characterized mainly by brain protein aggregates of tau (FTLD-Tau) or …

Progressive neurocognitive dysfunction is the leading cause of a reduced quality of life in
patients with primary brain tumours. Understanding the mechanisms underlying cognitive …

Worldwide, more than 50 million people live with dementia, and due to the rapidly aging
population, dementia cases are expected to increase at least five times in 2050. 30%–40 …

Age-associated white matter lesions (WML) are a common feature of the ageing brain, and
an independent risk factor for dementia. Deep subcortical lesions (DSCL) are associated …