[HTML][HTML] Current state and future directions in the therapy of ALS

L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Disease-modifying and symptomatic treatment of amyotrophic lateral sclerosis

J Dorst, AC Ludolph, A Huebers - Therapeutic advances in …, 2018 - journals.sagepub.com
In this review, we summarize the most important recent developments in the treatment of
amyotrophic lateral sclerosis (ALS). In terms of disease-modifying treatment options, several …

[HTML][HTML] Canadian best practice recommendations for the management of amyotrophic lateral sclerosis

C Shoesmith, A Abrahao, T Benstead, M Chum… - Cmaj, 2020 - Can Med Assoc
The care and management of patients with ALS should always be patient focused, with
attention to holistic and emotional aspects of well-being. It is the patient who ultimately …

[HTML][HTML] Skeletal muscle in ALS: an unappreciated therapeutic opportunity?

S Scaricamazza, I Salvatori, A Ferri, C Valle - Cells, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
selective degeneration of upper and lower motor neurons and by the progressive weakness …

[HTML][HTML] Effects of exercise on sleep in neurodegenerative disease

AA Memon, JJ Coleman, AW Amara - Neurobiology of disease, 2020 - Elsevier
As the population ages, the incidence and prevalence of neurodegenerative disorders will
continue to increase. Persons with neurodegenerative disease frequently experience sleep …

[HTML][HTML] Mixed comparison of different exercise interventions for function, respiratory, fatigue, and quality of life in adults with amyotrophic lateral sclerosis: Systematic …

Y Zhu, Y Xu, R Xuan, J Huang, B István… - Frontiers in Aging …, 2022 - frontiersin.org
Background Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease
whose primary hallmark is the progressive degeneration of motor neurons in the brainstem …

[HTML][HTML] The role of exercise as a non-pharmacological therapeutic approach for amyotrophic lateral sclerosis: beneficial or detrimental?

S Tsitkanou, P Della Gatta, V Foletta… - Frontiers in neurology, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, involves the rapid
deterioration of motor neurons resulting in severe muscle atrophy and respiratory …

Effects of exercise in patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis

L Meng, X Li, C Li, RCC Tsang, Y Chen… - American Journal of …, 2020 - journals.lww.com
Objective The aim of this study was to systematically review the efficacy and safety of
exercise in patients with amyotrophic lateral sclerosis (ALS). Design Randomized controlled …

Care management in amyotrophic lateral sclerosis

MH Soriani, C Desnuelle - Revue neurologique, 2017 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disease characterized by progressive weakness of voluntary muscles of …

[HTML][HTML] Effects of combined endurance and resistance training in Amyotrophic Lateral Sclerosis: A pilot, randomized, controlled study

A Merico, M Cavinato, C Gregorio… - European journal of …, 2018 - ncbi.nlm.nih.gov
Based on available evidence, muscle strengthening and cardiovascular exercises can help
maintain function and not adversely affect the progression of disease in patients with ALS …