The role of DEAD-box ATPases in gene expression and the regulation of RNA–protein condensates
DEAD-box ATPases constitute a very large protein family present in all cells, often in great
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …
abundance. From bacteria to humans, they play critical roles in many aspects of RNA …
The interchromatin compartment participates in the structural and functional organization of the cell nucleus
This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear
landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing …
landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing …
Polyploidy, the nucleotype, and novelty: the impact of genome doubling on the biology of the cell
Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …
Many aspects of polyploidy have been elucidated with the tools that have become available …
Emerging evidence of translational control by AU-rich element-binding proteins
H Otsuka, A Fukao, Y Funakami, KE Duncan… - Frontiers in …, 2019 - frontiersin.org
RNA-binding proteins (RBPs) are key regulators of posttranscriptional gene expression and
control many important biological processes including cell proliferation, development, and …
control many important biological processes including cell proliferation, development, and …
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets
B Decaesteker, G Denecker, C Van Neste… - Nature …, 2018 - nature.com
Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases.
Here, we perform an integrative epigenomics search for dosage-sensitive transcription …
Here, we perform an integrative epigenomics search for dosage-sensitive transcription …
Ran GTPase and its importance in cellular signaling and malignant phenotype
Ran is a member of the Ras superfamily of proteins, which primarily regulates
nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and …
nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and …
ALYREF mainly binds to the 5′ and the 3′ regions of the mRNA in vivo
The TREX complex (TREX) plays key roles in nuclear export of mRNAs. However, little is
known about its transcriptome-wide binding targets. We used individual cross-linking and …
known about its transcriptome-wide binding targets. We used individual cross-linking and …
Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection
The nuclear pore complex is the sole gateway connecting the nucleoplasm and cytoplasm.
In humans, the nuclear pore complex is one of the largest multiprotein assemblies in the cell …
In humans, the nuclear pore complex is one of the largest multiprotein assemblies in the cell …
RNA export through the nuclear pore complex is directional
A Ashkenazy-Titelman, MK Atrash, A Boocholez… - Nature …, 2022 - nature.com
The changes occurring in mRNA organization during nucleo-cytoplasmic transport and
export, are not well understood. Moreover, directionality of mRNA passage through the …
export, are not well understood. Moreover, directionality of mRNA passage through the …
The multifaceted role of PARP1 in RNA biogenesis
R Eleazer… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract Poly (ADP‐ribose) polymerases (PARPs) are abundant nuclear proteins that
synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p) ADPr to target …
synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p) ADPr to target …