Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

The anaerobic threshold (AT) remains a widely recognized, and contentious, concept in
exercise physiology and medicine. As conceived by Karlman Wasserman, the AT coalesced …

Mistakenly thought to be the consequence of oxygen lack in contracting skeletal muscle we
now know that the L-enantiomer of the lactate anion is formed under fully aerobic conditions …

Sepsis is the third leading cause of death worldwide and the main cause of mortality in
hospitals,–, but the best treatment strategy remains uncertain. In particular, evidence …

Once thought to be a waste product of anaerobic metabolism, lactate is now known to form
continuously under aerobic conditions. Shuttling between producer and consumer cells …

Lactate is an end product of glycolysis. As a critical energy source for mitochondrial
respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule …

After a century, it's time to turn the page on understanding of lactate metabolism and
appreciate that lactate shuttling is an important component of intermediary metabolism in …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported
as major contributors to non-trauma deaths in the emergency departments worldwide. The …

No longer viewed as a metabolic waste product and cause of muscle fatigue, a
contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in …