Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Articular cartilage serves as a low-friction, load-bearing tissue without the support with blood
vessels, lymphatics and nerves, making its repair a big challenge. Transforming growth …

Apoptosis is a highly-regulated, active process of cell death involved in development,
homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Cell death is a vital process that occurs in billions of cells in the human body every day. This
process helps maintain tissue homeostasis, supports recovery from acute injury, deals with …

Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than
half of the over 65 population. In the past, OA was considered a wear and tear disease …

Cell death with morphological and molecular features of apoptosis has been detected in
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …

Aging and inflammation are major contributing factors to the development and progression
of arthritic and musculoskeletal diseases.“Inflammaging” refers to low-grade inflammation …