NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …

Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of
damage. It is defined by a number of universal components, including oxidative stress …

Despite the initial success of some drugs and vaccines targeting COVID-19, understanding
the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is featured by intensive
inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis …

Background Neuroinflammation and mitochondrial impairment play important roles in the
neuropathogenesis of Parkinson's disease (PD). The activation of NLRP3 inflammasome …

Objectives NLRP3 inflammasome is a critical part of the innate immune system and plays an
important role in a variety of inflammatory diseases. However, the effects of NLRP3 …

Background Chemical liver injury is one of the main causes of acute liver failure and death.
To date, however, treatment strategies for acute liver injury have been limited. Therefore …

Acute inflammation is a key component of the immune system's response to pathogens, toxic
agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing …

Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

Neuroinflammation is a critical degradative condition affecting neurons in the brain.
Progressive neurodegenerative conditions such as Alzheimer's disease and Parkinson's …