[HTML][HTML] Treg cell-derived exosomes miR-709 attenuates microglia pyroptosis and promotes motor function recovery after spinal cord injury

W Xiong, C Li, G Kong, Q Zeng, S Wang, G Yin… - Journal of …, 2022 - Springer
Neuroinflammation is an important cause of poor prognosis in patients with spinal cord
injury. pyroptosis is a new type of inflammatory cell death. Treg cells has been shown to play …

[HTML][HTML] GSK-3β: An exuberating neuroinflammatory mediator in Parkinson's disease

SS Khan, S Janrao, S Srivastava, SB Singh… - Biochemical …, 2023 - Elsevier
Neuroinflammation is a critical degradative condition affecting neurons in the brain.
Progressive neurodegenerative conditions such as Alzheimer's disease and Parkinson's …

[HTML][HTML] Bruton's tyrosine kinase inhibitors (Btkis): review of Preclinical studies and evaluation of clinical trials

D Rozkiewicz, JM Hermanowicz, I Kwiatkowska… - Molecules, 2023 - mdpi.com
In the last few decades, there has been a growing interest in Bruton's tyrosine kinase (BTK)
and the compounds that target it. BTK is a downstream mediator of the B-cell receptor (BCR) …

Environmental pollutants induce NLRP3 inflammasome activation and pyroptosis: roles and mechanisms in various diseases

Y Mou, W Liao, Y Liang, Y Li, M Zhao, Y Guo… - Science of The Total …, 2023 - Elsevier
Environmental pollution is changing with economic development. Most environmental
pollutants are characterized by stable chemical properties, strong migration, potential …

[HTML][HTML] Mitochondria as key players in the pathogenesis and treatment of rheumatoid arthritis

SA Clayton, L MacDonald… - Frontiers in …, 2021 - frontiersin.org
Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

F Anaeigoudari, A Anaeigoudari… - Physiological …, 2023 - Wiley Online Library
Application of herbal medicines in the treatment of diseases is in the center of attention of
medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the …

[HTML][HTML] The role of HDAC6 in autophagy and NLRP3 inflammasome

P Chang, H Li, H Hu, Y Li, T Wang - Frontiers in Immunology, 2021 - frontiersin.org
Autophagy fights against harmful stimuli and degrades cytosolic macromolecules,
organelles, and intracellular pathogens. Autophagy dysfunction is associated with many …

Recent advances in the pharmacological applications and liver toxicity of triptolide

D Cui, D Xu, S Yue, C Yan, W Liu, R Fu, W Ma… - Chemico-Biological …, 2023 - Elsevier
Triptolide is a predominant active component of Triptergium wilfordii Hook. F, which has
been used for the treatment of cancers and autoimmune diseases such as rheumatoid …

Polypeptide from Moschus Suppresses Lipopolysaccharide-Induced Inflammation by Inhibiting NF-κ B-ROS/NLRP3 Pathway

J Yi, L Li, Z Yin, Y Quan, R Tan, S Chen, J Lang… - Chinese journal of …, 2023 - Springer
Objective To examine the anti-inflammatory effects and potential mechanisms of polypeptide
from Moschus (PPM) in lipopolysaccharide (LPS)-induced THP-1 macrophages and BALB/c …

Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors

T Ye, W Tao, X Chen, C Jiang, B Di, L Xu - Cytokine & Growth Factor …, 2023 - Elsevier
The Nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3
(NLRP3), a member of the nucleotide-binding oligomerization domain (NOD) like receptors …