Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …

Blood-brain barrier disruption plays an important role in central nervous system diseases.
This review provides information on the role of mitochondrial oxidative stress in brain …

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate
the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a …

Inflammation is an important part of the development of various organ diseases. The
inflammasome, as an innate immune receptor, plays an important role in the formation of …

NLRP3 inflammasome activation is implicated in the pathogenesis of a wide range of
inflammatory diseases, but medications targeting the NLRP3 inflammasome are not …

The gasdermin family is a newly identified class of pore-forming proteins that play as the
executioners of pyroptosis, a lytic pro-inflammatory type of cell death triggered by sensing …

Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even
leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis …

Aging reduces homeostasis and contributes to increasing the risk of brain diseases and
death. Some of the principal characteristics are chronic and low-grade inflammation, a …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a multi-protein signalling
complex integral to the chronic inflammatory response, activated in response to sterile and …

Dysfunction of mesangial cells plays a significant role in the glomerular lesions and is
implicated in the pathophysiology of diabetic nephropathy (DN). Macrophages infiltration is …