NLRP3 inflammasome in atherosclerosis: putting out the fire of inflammation

BZ Shao, HY Xu, YC Zhao, XR Zheng, F Wang… - Inflammation, 2023 - Springer
Atherosclerosis (AS) is a chronic inflammatory disease with thickening or hardening of the
arteries, which led to the built-up of plaques in the inner lining of an artery. Among all the …

[HTML][HTML] Mechanisms of neutrophil extracellular trap in chronic inflammation of endothelium in atherosclerosis

X Yang, Y Ma, X Chen, J Zhu, W Xue, K Ning - Life Sciences, 2023 - Elsevier
Cardiovascular diseases are a primary cause of morbidity and mortality around the world. In
addition, atherosclerosis (AS)-caused cardiovascular disease is the primary cause of death …

Therapeutic targeting of microtubule affinity‐regulating kinase 4 in cancer and neurodegenerative diseases

M Alam, S Ahmed, M Abid, GM Hasan… - Journal of Cellular …, 2023 - Wiley Online Library
Microtubule affinity‐regulating kinase 4 (MARK4) is a member of the Ser/Thr protein kinase
family, phosphorylates the microtubule‐connected proteins and plays a vital role in causing …

NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis

D Wang, Y Wu, S Sun, P Zhao, X Zhou, C Liang… - Science of The Total …, 2023 - Elsevier
Cadmium (Cd), a toxic heavy metal, exerts deleterious effects on neuronal survival and
cognitive function. NOD-like receptor 3 (NLRP3) inflammasome-dependent pyroptosis has …

Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury …

Y Wu, D Huang, X Wang, C Pei, W Xiao, F Wang… - International …, 2021 - Elsevier
Acute lung injury (ALI) is a common clinical condition with a high mortality rate and no
specific treatment is available. An excessive inflammatory response contributes to the …

Caspase-3/GSDME mediated pyroptosis: A potential pathway for sepsis

C Jiao, H Zhang, H Li, X Fu, Y Lin, C Cao, S Liu… - International …, 2023 - Elsevier
The inflammatory response is one of the host's mechanisms to combat pathogens. Normal
and controlled inflammation can accelerate the clearance of pathogens. However, in sepsis …

NLRP3-mediated pyroptosis in diabetic nephropathy

J Wan, D Liu, S Pan, S Zhou, Z Liu - Frontiers in pharmacology, 2022 - frontiersin.org
Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD), which is
characterized by a series of abnormal changes such as glomerulosclerosis, podocyte loss …

[HTML][HTML] Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier …

S Zhou, Y Li, Y Hong, Z Zhong, M Zhao - European Journal of …, 2023 - Elsevier
Puerarin (Pue), an isoflavone compound extracted from Pueraria, has been shown to inhibit
inflammation and reduce cerebral edema. The neuroprotective effect of puerarin has …

Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

C Lv, T Cheng, B Zhang, K Sun, K Lu - Renal Failure, 2023 - Taylor & Francis
Objectives Diabetic nephropathy (DN) is the most common microvascular complication of
diabetes mellitus. This study investigated the mechanism of triptolide (TP) in podocyte injury …

NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation

Z Wang, G Xu, Z Li, X Xiao, J Tang… - Journal of Inflammation …, 2022 - Taylor & Francis
Inflammation is the tissues' defense response after the body is stimulated by microbial
infection or damage signals, and it is initiated when pattern recognition receptors recognize …