The ability to replace organs and tissues on demand could save or improve millions of lives
each year globally and create public health benefits on par with curing cancer. Unmet needs …

In this concept article, we outline a variety of new approaches that have been conceived to
address some of the remaining challenges for developing improved methods of …

Short-term patient and graft outcomes continue to improve after kidney and liver
transplantation, with 1-year survival rates over 80%; however, improving longer-term …

Organ transplantation is the most effective therapy for patients with end-stage disease.
Preservation solutions and techniques are crucial for donor organ quality, which is directly …

Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and
resuscitate organs likely to be declined for transplantation, thereby increasing the number of …

Importance Continuous hypothermic machine perfusion during organ preservation has a
beneficial effect on graft function and survival in kidney transplant when compared with static …

Normothermic machine perfusion (NMP) technologies are emerging as an important adjunct
in organ preservation and transplantation. NMP can enable the reduction or avoidance of …

The increased demand for organs has led to the increased usage of “higher risk” kidney and
liver grafts. These grafts from donation after circulatory death or expanded criteria donors …

The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

Ex vivo normothermic machine perfusion (NMP) of donor kidneys prior to transplantation
provides a platform for direct delivery of cellular therapeutics to optimize organ quality prior …