The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …

Ovarian cancer is one of the most common gynecologic cancers and has the highest
mortality rate of any other cancer of the female reproductive system. Epithelial ovarian …

Chemoresistance represents a major obstacle to the treatment of human cancers. Increased
DNA repair capacity is one of the important mechanisms underlying chemoresistance. In …

Cancer is one of the leading causes of death worldwide. Many treatments have been
developed so far, although effective, suffer from severe side effects due to low selectivity …

Prostate cancer ranks fifth in cancer-related mortality in men worldwide. DNA damage is
implicated in cancer and DNA damage response (DDR) pathways are in place against this …

The human ATR gene encodes a kinase that is activated by DNA damage and replication
stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR …

Somatic mutations are an inevitable component of ageing and the most important cause of
cancer. The rates and types of somatic mutation vary across individuals, but relatively few …

F-box proteins (FBP) are the substrate specifying subunit of Skp1-Cul1-FBP (SCF)-type E3
ubiquitin ligases and are responsible for directing the ubiquitination of numerous proteins …

Therapy resistance is a major hurdle to the treatment of human malignant tumors. Both DNA
damage repair and stem-like properties contribute to chemoresistance and radioresistance …

DNA-damaging agents and endogenous DNA damage constantly harm genome integrity.
Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in …