Objectives/Hypothesis Recent reviews of laryngeal cancer have detected a trend toward
reduced survival, linked temporally to an abrupt change in treatment of these patients during …

Squamous cell carcinoma of the hypopharynx represents a distinct clinical entity. Most
patients present with significant comorbidities and advanced‐stage disease. The overall …

It has been documented previously that defects in the generation of C18-ceramide, a
product of ceramide synthase 1 (CerS1), also known as longevity assurance gene 1 …

Objectives/Hypothesis The objective was to characterize incidence, treatment, and survival
for hypopharyngeal cancer in the United States between 1988 and 2010, and to analyze …

Background: Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive
malignancy with one of the worst prognoses among all head and neck cancers. Greater …

Reconstruction of circumferential pharyngeal defects following total pharyngolaryngectomy
presents major challenges with respect to surgical morbidity and restoration of functional …

The reconstructive armamentarium of head and neck surgeons involved in hypopharyngeal
and cervical esophagus reconstruction should encompass every option described herein in …

Background: Advanced hypopharyngeal carcinoma has a dismal prognosis. The optimal
treatment for these patients remains under debate. This systematic review aimed to compare …

BACKGROUND: The Jejunal Free Flap (JFF) was first described by Seidenberg in 1957 for
the reconstruction of pharyngolryngectomy defects. Historically, its outcome profile has been …

Background The oncologic and functional outcome of transoral laser microsurgery (TLM) for
primary treatment of hypopharyngeal cancer was examined in a multimodal treatment …