Oxygen (O 2) is an essential nutrient that serves as a key substrate in cellular metabolism
and bioenergetics. In a variety of physiological and pathological states, organisms …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided
new insights into the pathogenesis of anaemia associated with renal failure and has led to …

The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival,
proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly …

The application of molecular techniques to exercise biology has provided novel insight into
the complexity and breadth of intracellular signaling networks involved in response to …

Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal
obliteration is a major contributor to the elevated pulmonary vascular resistance in patients …

The nuclear factor-κB (NF-κB) signalling pathway regulates immune responses and is
implicated in the pathogenesis of many inflammatory diseases. Given the well established …

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the
hypoxic induction of red blood cell production. Efforts to understand the molecular basis of …

Metazoan life is dependent upon the utilization of O2 for essential metabolic processes and
oxygen homeostasis is an organizing principle for understanding metazoan evolution …