Lysosomes in retinal health and disease
P Boya, K Kaarniranta, JT Handa, D Sinha - Trends in neurosciences, 2023 - cell.com
Lysosomes play crucial roles in various cellular processes–including endocytosis,
phagocytosis, and autophagy–which are vital for maintaining retinal health. Moreover, these …
phagocytosis, and autophagy–which are vital for maintaining retinal health. Moreover, these …
[HTML][HTML] Aging of the eye: Lessons from cataracts and age-related macular degeneration
A Cvekl, J Vijg - Ageing Research Reviews, 2024 - Elsevier
Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …
Geroscience aims to understand the effects of the aging process on these diseases …
Reduced Retinal Pigment Epithelial Autophagy Due to Loss of Rab12 Prenylation in a Human iPSC-RPE Model of Choroideremia
MÖ Raeker, ND Perera, AJ Karoukis, L Chen… - Cells, 2024 - mdpi.com
Choroideremia is an X-linked chorioretinal dystrophy caused by mutations in CHM,
encoding Rab escort protein 1 (REP-1), leading to under-prenylation of Rab GTPases …
encoding Rab escort protein 1 (REP-1), leading to under-prenylation of Rab GTPases …
[HTML][HTML] Transcriptomic changes predict metabolic alterations in LC3 associated phagocytosis in aged mice
A Dhingra, JW Tobias, NJ Philp… - International Journal of …, 2023 - mdpi.com
LC3b (Map1lc3b) plays an essential role in canonical autophagy and is one of several
components of the autophagy machinery that mediates non-canonical autophagic functions …
components of the autophagy machinery that mediates non-canonical autophagic functions …
[HTML][HTML] Therapeutic potential of lithium chloride and valproic acid against neuronopathic types of mucopolysaccharidoses through induction of the autophagy process
L Gaffke, N Firyn, E Rintz, K Pierzynowska… - Archives of Biochemistry …, 2023 - Elsevier
Mucopolysaccharidoses (MPS) are a group of inherited disorders, caused by mutations in
the genes coding for proteins involved (directly or indirectly) in glycosaminoglycan (GAG) …
the genes coding for proteins involved (directly or indirectly) in glycosaminoglycan (GAG) …
Regulation of transforming growth factor β2-induced epithelial-mesenchymal transition and autophagy in lens epithelial cells by the miR-492/NPM1 axis
Y Bao, G Ding, H Yu, Y He, J Wu - Biomolecules and Biomedicine, 2024 - bjbms.org
A cataract is a clinically common blinding disease closely related to the ageing of the eye
cells, which has become a major health killer in the elderly. Our research seeks to analyze …
cells, which has become a major health killer in the elderly. Our research seeks to analyze …