Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps

D De Luca, P Cogo, MC Kneyber, P Biban, MG Semple… - Critical Care, 2021 - Springer
Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have
different age-specific characteristics and definitions. Trials on surfactant for ARDS in children …

Respiratory distress syndrome in preterm neonates in the era of precision medicine: A modern critical care-based approach

D De Luca - Pediatrics & Neonatology, 2021 - Elsevier
Respiratory distress syndrome (RDS) was recognized to be caused by primary surfactant
deficiency almost 70 years ago and continuous positive airway pressure was introduced …

Antiviral effect of budesonide against SARS-CoV-2

N Heinen, TL Meister, M Klöhn, E Steinmann, D Todt… - Viruses, 2021 - mdpi.com
Treatment options for COVID-19, a disease caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) infection, are currently severely limited. Therefore, antiviral …

Pulmonary surfactant: a unique biomaterial with life-saving therapeutic applications

B Pioselli, F Salomone, G Mazzola… - Current Medicinal …, 2022 - ingentaconnect.com
Pulmonary surfactant is a complex lipoprotein mixture secreted into the alveolar lumen by
type 2 pneumocytes, which is composed by tens of different lipids (approximately 90% of its …

Strategies to protect surfactant and enhance its activity

D De Luca, C Autilio - biomedical journal, 2021 - Elsevier
The knowledge about surfactant biology is now deeper and recent research has allowed to
clarify its role in several human lung disorders. The balance between surfactant production …

Thermodynamic and Structural Study of Budesonide—Exogenous Lung Surfactant System

A Keshavarzi, A Asi Shirazi, R Korfanta… - International Journal of …, 2024 - mdpi.com
The clinical benefits of using exogenous pulmonary surfactant (EPS) as a carrier of
budesonide (BUD), a non-halogenated corticosteroid with a broad anti-inflammatory effect …

[HTML][HTML] The Effect of Budesonide Delivered by High-Frequency Oscillatory Ventilation on Acute Inflammatory Response in Severe Lung Injury in Adult Rabbits

N Nemcova, P Kosutova, M Kolomaznik… - Physiological …, 2023 - ncbi.nlm.nih.gov
The inflammation present in acute respiratory distress syndrome (ARDS) and thereby
associated injury to the alveolar-capillary membrane and pulmonary surfactant can …

[PDF][PDF] Meta-analysis of the efficacy of budesonide and ambroxol hydrochloride inhalation in children with pneumonia and their effects on inflammatory response

H Shen, X Zhao, L Xu - Heliyon, 2023 - cell.com
Childhood pneumonia, often caused by acute upper respiratory tract infections or bronchitis,
is one of the leading causes of mortality in children. Nebulized inhalation, as a low-risk …

MiR-338-3p Is a Biomarker in Neonatal Acute Respiratory Distress Syndrome (ARDS) and Has Roles in the Inflammatory Response of ARDS Cell Models

C Zhang, Y Ji, Q Wang, L Ruan - Acta Medica Okayama, 2022 - ousar.lib.okayama-u.ac.jp
To investigate the association between serum miR-338-3p levels and neonatal acute
respiratory distress syndrome (ARDS) and its mechanism. The relative miR-338-3p …

[PDF][PDF] Siblings with Severe Neonatal ARDS: Immune Deficiency Versus COVID-19

C Armağan, TÜ Egeli, SA Can Akyıldız… - ANATOLIAN …, 2024 - jag.journalagent.com
Neonatal acute respiratory distress syndrome (ARDS) is a relatively new diagnosis. Specific
treatment, beyond managing the underlying disease, generally relies on lung protective …