New insights into activation and function of the AMPK

GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Gut microbiota-derived metabolites as central regulators in metabolic disorders

A Agus, K Clément, H Sokol - Gut, 2021 - gut.bmj.com
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

A unified catalog of 204,938 reference genomes from the human gut microbiome

A Almeida, S Nayfach, M Boland, F Strozzi… - Nature …, 2021 - nature.com
Comprehensive, high-quality reference genomes are required for functional characterization
and taxonomic assignment of the human gut microbiota. We present the Unified Human …

[HTML][HTML] Role and mechanism of gut microbiota in human disease

Y Chen, J Zhou, L Wang - Frontiers in cellular and infection …, 2021 - frontiersin.org
The human gut microbiome is a huge microbial community that plays an irreplaceable role
in human life. With the further development of research, the influence of intestinal flora on …

[PDF][PDF] Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

J Roswall, LM Olsson, P Kovatcheva-Datchary… - Cell host & …, 2021 - cell.com
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is
established at birth. However, the succession by which different bacteria are incorporated …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Profile of the gut microbiota of adults with obesity: a systematic review

L Crovesy, D Masterson, EL Rosado - European journal of clinical …, 2020 - nature.com
Recently, relationship between gut microbiota composition and development of obesity has
been pointed. However, the gut microbiota composition of individual with obesity is not …

Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

[HTML][HTML] Polyphenol-mediated gut microbiota modulation: Toward prebiotics and further

MC Rodríguez-Daza, EC Pulido-Mateos… - Frontiers in …, 2021 - frontiersin.org
The genome of gut microbes encodes a collection of enzymes whose metabolic functions
contribute to the bioavailability and bioactivity of unabsorbed (poly) phenols. Datasets from …