New insights into activation and function of the AMPK
GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …
Gut microbiota-derived metabolites as central regulators in metabolic disorders
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …
Gut microbiota in human metabolic health and disease
Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
A unified catalog of 204,938 reference genomes from the human gut microbiome
Comprehensive, high-quality reference genomes are required for functional characterization
and taxonomic assignment of the human gut microbiota. We present the Unified Human …
and taxonomic assignment of the human gut microbiota. We present the Unified Human …
[HTML][HTML] Role and mechanism of gut microbiota in human disease
Y Chen, J Zhou, L Wang - Frontiers in cellular and infection …, 2021 - frontiersin.org
The human gut microbiome is a huge microbial community that plays an irreplaceable role
in human life. With the further development of research, the influence of intestinal flora on …
in human life. With the further development of research, the influence of intestinal flora on …
[PDF][PDF] Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
J Roswall, LM Olsson, P Kovatcheva-Datchary… - Cell host & …, 2021 - cell.com
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is
established at birth. However, the succession by which different bacteria are incorporated …
established at birth. However, the succession by which different bacteria are incorporated …
[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …
several types of adipose tissue have been identified, namely white, brown, and beige, that …
Profile of the gut microbiota of adults with obesity: a systematic review
L Crovesy, D Masterson, EL Rosado - European journal of clinical …, 2020 - nature.com
Recently, relationship between gut microbiota composition and development of obesity has
been pointed. However, the gut microbiota composition of individual with obesity is not …
been pointed. However, the gut microbiota composition of individual with obesity is not …
Signaling pathways in obesity: mechanisms and therapeutic interventions
X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …
excessive fat accumulation in the body, obesity sharply increases the risk of several …
[HTML][HTML] Polyphenol-mediated gut microbiota modulation: Toward prebiotics and further
MC Rodríguez-Daza, EC Pulido-Mateos… - Frontiers in …, 2021 - frontiersin.org
The genome of gut microbes encodes a collection of enzymes whose metabolic functions
contribute to the bioavailability and bioactivity of unabsorbed (poly) phenols. Datasets from …
contribute to the bioavailability and bioactivity of unabsorbed (poly) phenols. Datasets from …