Global prevalence and clinical characteristics of metabolic-associated fatty liver disease: a meta-analysis and systematic review of 10 739 607 individuals

KE Chan, TJL Koh, ASP Tang, J Quek… - The Journal of …, 2022 - academic.oup.com
Abstract Background and Aims Metabolic-associated fatty liver disease (MAFLD) was
proposed as a better definition of nonalcoholic fatty liver disease (NAFLD) to encompass the …

Advances in our understanding of the molecular heterogeneity of fatty liver disease: toward informed treatment decision making

CJ Pirola, S Sookoian - Expert Review of Gastroenterology & …, 2023 - Taylor & Francis
Introduction nonalcoholic fatty liver disease (NAFLD) is a complex disorder resulting from
intricate relationships with diverse cardiometabolic risk factors and environmental factors …

The spectrum and impact of metabolic dysfunction in MAFLD: A longitudinal cohort analysis of 32,683 overweight and obese individuals

KE Chan, CH Ng, CE Fu, J Quek, G Kong… - Clinical …, 2023 - Elsevier
Background Metabolic associated fatty liver disease (MAFLD) was recently proposed as an
alternative name change for better encapsulation of disease. However, there exists a …

Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease

OO Badmus, ZA Kipp, EA Bates… - American Journal …, 2023 - journals.physiology.org
The leading cause of death in patients with nonalcoholic fatty liver disease (NAFLD) is
cardiovascular disease (CVD). However, the mechanisms are unknown. Mice deficient in …

Metabolic associated fatty liver disease better identifying patients at risk of liver and cardiovascular complications

YM Cheng, CC Wang, JH Kao - Hepatology International, 2023 - Springer
Background/purpose A nomenclature of “metabolic associated fatty liver disease”(MAFLD)
with a new definition was proposed in 2020 instead of the previous “non-alcoholic fatty liver …

[HTML][HTML] Systematic analysis of long non-coding RNA genes in nonalcoholic fatty liver disease

M Ilieva, J Dao, HE Miller, JH Madsen, AJR Bishop… - Non-coding RNA, 2022 - mdpi.com
The largest solid organ in humans, the liver, performs a variety of functions to sustain life.
When damaged, cells in the liver can regenerate themselves to maintain normal liver …

[HTML][HTML] Non-Alcoholic Fatty Liver Disease Is Associated with a Decreased Catalase (CAT) Level, CT Genotypes and the T Allele of the -262 C/T CAT Polymorphism

M Kosmalski, I Szymczak-Pajor, J Drzewoski… - Cells, 2023 - mdpi.com
Background: It is well known that oxidative stress plays an important role in the development
of non-alcoholic fatty liver disease (NAFLD). It has been suggested that an insufficient …

[HTML][HTML] The Impact and Burden of Dietary Sugars on the Liver

HE Huneault, AR Tovar… - Hepatology …, 2023 - journals.lww.com
NAFLD, or metabolic dysfunction–associated steatotic liver disease, has increased in
prevalence hand in hand with the rise in obesity and increased free sugars in the food …

[HTML][HTML] Cellular heterogeneity and plasticity during NAFLD progression

HJ Park, J Choi, H Kim, DY Yang, TH An… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to
nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma …

[HTML][HTML] Liver steatosis: a marker of metabolic risk in children

CR Neri, S Scapaticci, F Chiarelli… - International Journal of …, 2022 - mdpi.com
Obesity is one of the greatest health challenges affecting children of all ages and ethnicities.
Almost 19% of children and adolescents worldwide are overweight or obese, with an …