Ageing of the central nervous system (CNS) is the major risk factor for Alzheimer's disease
(AD), a type of neurodegeneration that is associated with deficits in cognition and memory …

The most notable finding in neurodegenerative diseases is the progressive death of
neurones cells. Yet, neuroglial changes can precede and facilitate neuronal loss. This is …

The Calcium-Sensing Receptor (CaSR) is a G-protein coupled, 7-transmembrane domain
receptor ubiquitously expressed throughout the body, brain including. The role of CaSR in …

Background: It is well known that alterations in astrocytes occur in Alzheimer's disease and
reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that …

Oxaliplatin is one of the most widely used anticancer drugs representing the cornerstone of
the treatment of colorectal cancer. Yet a number of side effects, including oxaliplatin-induced …

From birth to death, neurons are dynamically accompanied by neuroglial cells in a very
close morphological and functional relationship. Three families have been classically …

Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain
and originally isolated from pheochromocytoma cells. In addition to its vasoactive properties …

Astrocytes perform fundamental housekeeping functions in the central nervous system and
through bidirectional communication with neurons are thought to coordinate synaptic …

Calcineurin (CaN), acting downstream of intracellular calcium signals, orchestrates cellular
remodeling in many cellular types. In astrocytes, major homeostatic players in the central …

Recent data indicate that Alzheimer's disease (AD) is associated with disturbances of the
circadian rhythm in patients. We examined the effect of amyloid-β (Aβ) peptide, the main …