Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Cell death is an important component of the pathophysiology of cardiovascular disease. An
understanding of how cardiomyocytes die, and why regeneration of cells in the heart is …

Iron homeostasis disturbance has been implicated in Alzheimer's disease (AD), and excess
iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form …

Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation
of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine (15-HpETE-PE), generated …

Ferroptosis is a form of cell death primed by iron and lipid hydroperoxides and prevented by
GPx4. Ferrostatin-1 (fer-1) inhibits ferroptosis much more efficiently than phenolic …