Caveolin-1 in endothelial cells: A potential therapeutic target for atherosclerosis

Y Shu, S Jin - Heliyon, 2023 - cell.com
Atherosclerosis (AS) is a chronic vascular disease characterized by lipid accumulation and
the activation of the inflammatory response; it remains the leading nation-wide cause of …

[HTML][HTML] Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology

D Basavarajappa, C Galindo-Romero, V Gupta… - Molecular Aspects of …, 2023 - Elsevier
Glaucoma is a complex multifactorial eye disease manifesting in retinal ganglion cell (RGC)
death and optic nerve degeneration, ultimately causing irreversible vision loss. Research in …

Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane

X Chen, J Yang, H Cao, X Fang, S Liu, L Zou, J Yu… - Phytomedicine, 2023 - Elsevier
Background Dengue virus (DENV) is a major public health threat. However, there are no
specific therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang …

The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E …

X Mu, SJ Liu, LY Zheng, C Ouyang… - Free Radical Biology …, 2024 - Elsevier
Oxidized low density lipoprotein (oxLDL)-induced endothelial oxidative damage promotes
the development of atherosclerosis. Caveolae play an essential role in maintaining the …

DHCR24 insufficiency promotes vascular endothelial cell senescence and endothelial dysfunction via inhibition of Caveolin-1/ERK signaling

H Li, Z Yang, W Liang, H Nie, Y Guan… - The Journals of …, 2024 - academic.oup.com
Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-
related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other …

Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina

Y Wang, M Halawa, A Chatterjee, R Eshwaran, Y Qiu… - Molecular …, 2023 - Springer
Abstract Background Caveolin-1 (Cav-1) is a pivotal protein in the plasma membrane.
Studies on homozygous Cav-1 deficient mice revealed that Cav-1 is essential for endothelial …

[HTML][HTML] Value and Significance of Hypofluorescent Lesions Seen on Late-Phase Indocyanine Green Angiography

A Gaudric - Ophthalmology Science, 2024 - Elsevier
Background and Purpose The hypofluorescence of fundus lesions observed during the late
phase of indocyanine green angiography (ICGA) in various diseases has often been …

[HTML][HTML] Transcriptomic profiling of Schlemm's canal cells reveals a lymphatic-biased identity and three major cell states

R Balasubramanian, K Kizhatil, T Li, N Tolman… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Schlemm's canal (SC) is central in intraocular pressure regulation but requires much
characterization. It has distinct inner and outer walls, each composed of Schlemm's canal …

Identification of Structures Labeled by Indocyanine Green in the Rat Choroid and Retina Can Guide Interpretation of Indocyanine Green Angiography

D Mejlachowicz, P Lassiaz, M Zola… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Indocyanine green (ICG) is an albumin and lipoprotein binding dye absorbing in
the far red used in angiography to visualize choroidal vessels (ICG angiography [ICGA]). To …

The roles of Transient Receptor Potential (TRP) channels and aberrant calcium signalling in blood-retinal barrier dysfunction

S Dragoni, F Moccia, MD Bootman - … Biology [Submitted to], 2023 - oro.open.ac.uk
The inner blood-retinal barrier (iBRB) protects the retinal vasculature from the peripheral
circulation. Endothelial cells (ECs) are the core component of the iBRB; their close …