Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

X Zhong, X He, Y Wang, Z Hu, H Huang, S Zhao… - Journal of hematology & …, 2022 - Springer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

The Warburg effect 97 years after its discovery

RM Pascale, DF Calvisi, MM Simile, CF Feo, F Feo - Cancers, 2020 - mdpi.com
Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

Y Wang, JH Lu, QN Wu, Y Jin, DS Wang, YX Chen… - Molecular cancer, 2019 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) play nonnegligible roles in the
epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that …

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

N Hay - Nature Reviews Cancer, 2016 - nature.com
In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …

Drosophila melanogaster: A Model Organism to Study Cancer

Z Mirzoyan, M Sollazzo, M Allocca, AM Valenza… - Frontiers in …, 2019 - frontiersin.org
Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth

M Yuan, B Tu, H Li, H Pang, N Zhang, M Fan, J Bai… - Nature cancer, 2022 - nature.com
Cancer-associated fibroblasts (CAFs) are one of the most prominent and active components
in the pancreatic tumor microenvironment. Our data show that CAFs are critical for survival …

Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer

SK Chun, BM Fortin, RC Fellows, AN Habowski… - Science …, 2022 - science.org
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the
underlying molecular mechanism remains undefined. Suspected risk factors of young onset …

Glucose metabolism and glucose transporters in breast cancer

E Shin, JS Koo - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Breast cancer is the most common malignancy in women worldwide and is associated with
high mortality rates despite the continuously advancing treatment strategies. Glucose is …

LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

Q Hua, M Jin, B Mi, F Xu, T Li, L Zhao, J Liu… - Journal of hematology & …, 2019 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) have been associated with non-
small cell lung cancer (NSCLC), but the underlying molecular mechanisms of their specific …

Rewiring urea cycle metabolism in cancer to support anabolism

R Keshet, P Szlosarek, A Carracedo, A Erez - Nature Reviews Cancer, 2018 - nature.com
Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the
anabolic synthesis of macromolecules that are required during tumour proliferation and …