Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Extracting behavioral measurements non-invasively from video is stymied by the fact that it is
a hard computational problem. Recent advances in deep learning have tremendously …

Despite their ubiquitous presence, placebos and placebo effects retain an ambiguous and
unsettling presence in biomedicine. Specifically focused on chronic pain, this review …

Reliable and objective biomarkers promise to improve the assessment and treatment of
chronic pain. Resting-state electroencephalography (EEG) is broadly available, easy to use …

In humans, tissue injury and depression can both cause pain hypersensitivity, but whether
this involves distinct circuits remains unknown. Here, we identify two discrete glutamatergic …

Mechanism-based classification of pain has been advocated widely to aid tailoring of
interventions for individuals experiencing persistent musculoskeletal pain. Three pain …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Individual differences in pain perception are of interest in basic and clinical research as
altered pain sensitivity is both a characteristic and a risk factor for many pain conditions. It is …

Objectives: Improvements in pain management might be achieved by matching treatment to
underlying mechanisms for pain persistence. Many authors argue for a mechanism-based …

Chronic pain is a disabling disease with limited treatment options. While animal models
have revealed important aspects of pain neurobiology, therapeutic translation of this …