KRAS is the most frequently mutated oncogene in human cancer. In addition to holding this
distinction, unsuccessful attempts to target this protein have led to the characterization of …

KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …

Ras proteins play a crucial role as a central component of the cellular networks controlling a
variety of signaling pathways that regulate growth, proliferation, survival, differentiation …

Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a
common event in childhood acute lymphoblastic leukemia and is caused by point mutation …

K-Ras proteins are major drivers of human cancers, playing a direct causal role in about one
million cancer cases/year. In cancers driven by mutant K-Ras, the protein is locked in the …

Clonal evolution and intratumoral heterogeneity drive cancer progression through unknown
molecular mechanisms. To address this issue, functional differences between single T cell …

RAS proteins are key signaling switches essential for control of proliferation, differentiation,
and survival of eukaryotic cells. RAS proteins are mutated in 30% of human cancers. In …

Mutations that deregulate Notch1 and Ras/phosphoinositide 3 kinase (PI3K)/Akt signalling
are prevalent in T-cell acute lymphoblastic leukaemia (T-ALL), and often coexist. Here we …

Activation of mitogenic signaling pathways is a common oncogenic driver of many solid
tumors including lung cancer. Although activating mutations in the mitogen-activated protein …

Oncogenic mutations in RAS provide a compelling yet intractable therapeutic target. Using
co-immunoprecipitation mass spectrometry, we uncovered an interaction between RAS and …