SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

AD Proal, MB VanElzakker, S Aleman, K Bach… - Nature …, 2023 - nature.com
Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

Distinguishing features of Long COVID identified through immune profiling

J Klein, J Wood, JR Jaycox, RM Dhodapkar, P Lu… - Nature, 2023 - nature.com
Post-acute infection syndromes may develop after acute viral disease. Infection with SARS-
CoV-2 can result in the development of a post-acute infection syndrome known as long …

[HTML][HTML] Serotonin reduction in post-acute sequelae of viral infection

AC Wong, AS Devason, IC Umana, TO Cox… - Cell, 2023 - cell.com
Post-acute sequelae of COVID-19 (PASC," Long COVID") pose a significant global health
challenge. The pathophysiology is unknown, and no effective treatments have been found to …

Challenges and opportunities in long COVID research

RE Hamlin, CA Blish - Immunity, 2024 - cell.com
Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-
CoV-2 infection but rather have persistent or new symptoms for months to years following …

Association of nirmatrelvir for acute SARS‐CoV‐2 infection with subsequent Long COVID symptoms in an observational cohort study

MS Durstenfeld, MJ Peluso, F Lin… - Journal of Medical …, 2024 - Wiley Online Library
Oral nirmatrelvir/ritonavir is approved as treatment for acute COVID‐19, but the effect of
treatment during acute infection on risk of Long COVID is unknown. We hypothesized that …

The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China

W Zuo, D He, C Liang, S Du, Z Hua, Q Nie… - The Lancet Infectious …, 2024 - thelancet.com
Background Growing evidence suggests that symptoms associated with post-COVID-19
condition (also known as long COVID) can affect multiple organs and systems in the human …

[HTML][HTML] Vaccination after developing long COVID: Impact on clinical presentation, viral persistence, and immune responses

M Nayyerabadi, L Fourcade, SA Joshi… - International Journal of …, 2023 - Elsevier
Background Vaccination protects against severe COVID-19 manifestations. For those with
post-COVID-19 conditions (PCC) or long COVID, the impact of COVID-19 vaccination on the …

Systems analysis of innate and adaptive immunity in Long COVID

MJ Peluso, M Abdel-Mohsen, TJ Henrich… - Seminars in …, 2024 - Elsevier
Since the onset of the COVID-19 pandemic, significant progress has been made in
developing effective preventive and therapeutic strategies against severe acute SARS-CoV …

Three-year outcomes of post-acute sequelae of COVID-19

M Cai, Y Xie, EJ Topol, Z Al-Aly - Nature medicine, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes post-
acute sequelae of coronavirus disease 2019 (COVID-19)(PASC) in many organ systems …

Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies—An Interim Report

E Stein, C Heindrich, K Wittke, C Kedor, L Kim… - Journal of Clinical …, 2023 - mdpi.com
There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). SARS-CoV-2 has now become the …