A1 adenosine receptor agonists: medicinal chemistry and therapeutic potential

SA Hutchinson, PJ Scammells - Current pharmaceutical design, 2004 - ingentaconnect.com
Adenosine receptors are widely distributed in the body and modulate numerous
physiological processes. Four receptor subtypes (termed A1, A2A, A2B and A3) have been …

Adenosine receptor‐mediated modulation of acetylcholine release from rat striatal synaptosomes

KA Kirkpatrick, PJ Richardson - British journal of pharmacology, 1993 - Wiley Online Library
1 The effects of A1 and A2a adenosine receptor agonists on the veratridine‐evoked release
of [3H]‐acetylcholine ([3H]‐ACh) from rat striatal synaptosomes was investigated by use of …

[PDF][PDF] Functional expression of adenosine A2b receptor in Xenopus oocytes.

JL Yakel, RA Warren, SM Reppert, RA North - Molecular pharmacology, 1993 - Citeseer
SUMMARY RNA was transcribed in vitro from a cDNA clone (RFL9) that encodes the rat
adenosine A2b receptor. Xenopus oocytes that had been injected with this RNA several …

Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells

SPH Alexander, J Cooper, J Shine… - British journal of …, 1996 - Wiley Online Library
1 An [3H]‐adenine pre‐labelling methodology was employed to assay cyclic AMP
generation by adenosine analogues in Chinese hamster ovary (CHO. A2B4) cells …

Purinoceptor modulation of noradrenaline release in rat tail artery: tonic modulation mediated by inhibitory P2Y‐ and facilitatory A2A‐purinoceptors

J Gonçalves, G Queiroz - British journal of pharmacology, 1996 - Wiley Online Library
1 The effects of analogues of adenosine and ATP on noradrenaline release elicited by
electrical stimulation (5 Hz, 2700 pulses) were studied in superfused preparations of rat tail …

Reduction in cerebral ischemic injury in the newborn rat by potentiation of endogenous adenosine

JM Gidday, JC Fitzgibbons, AR Shah, MJ Kraujalis… - Pediatric …, 1995 - nature.com
Because of ontogenic influences on the pathophysiologic mechanisms of brain injury in the
perinatal brain, and in particular, the incomplete development of adenosine receptor …

[PDF][PDF] Characterization of adenosine receptors in human erythroleukemia cells and platelets: further evidence for heterogeneity of adenosine A2 receptor subtypes.

I Feoktistov, I Biaggioni - Molecular pharmacology, 1993 - Citeseer
Adenosine receptors are present in platelets, and their activation results in accumulation of
cAMP and inhibition of aggregation. The study of platelet adenosine receptors, however, is …

Enabling role of adenosine A1 receptors in adenosine A2A receptor‐mediated striatal expression of c‐fos

M Karcz‐Kubicha, D Quarta, BT Hope… - European Journal of …, 2003 - Wiley Online Library
When striatal neurons are strongly activated they produce adenosine, which activates
nearby adenosine A1 receptors (A1Rs) and adenosine A2A receptors (A2ARs). Although …

Modulation by adenosine of Aδ and C primary-afferent glutamatergic transmission in adult rat substantia gelatinosa neurons

LJ Lao, Y Kawasaki, K Yang, T Fujita, E Kumamoto - Neuroscience, 2004 - Elsevier
The present study examined the actions of adenosine on monosynaptic Aδ and C primary-
afferent excitatory postsynaptic currents (EPSCs) recorded from substantia gelatinosa (SG) …

The Adenosine Receptors Present on the Plasma Membrane of Chromaffin Cells Are of the A2b Subtype

V Casadó, T Casillas, J Mallol, EI Canela… - Journal of …, 1992 - Wiley Online Library
The adenosine receptors in the plasma membrane of chromaffin cells from bovine adrenal
medulla were characterized. The presence of A1 receptors was discounted owing to the …