Quantitative mass spectrometry imaging of biological systems

D Unsihuay, D Mesa Sanchez… - Annual review of physical …, 2021 - annualreviews.org
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

High spatial resolution imaging of biological tissues using nanospray desorption electrospray ionization mass spectrometry

R Yin, KE Burnum-Johnson, X Sun, SK Dey, J Laskin - Nature Protocols, 2019 - nature.com
Mass spectrometry imaging (MSI) enables label-free spatial mapping of hundreds of
biomolecules in tissue sections. This capability provides valuable information on tissue …

[HTML][HTML] Advances in structure elucidation of small molecules using mass spectrometry

T Kind, O Fiehn - Bioanalytical reviews, 2010 - Springer
The structural elucidation of small molecules using mass spectrometry plays an important
role in modern life sciences and bioanalytical approaches. This review covers different soft …

Mass spectrometry imaging for clinical research–latest developments, applications, and current limitations

PM Vaysse, RMA Heeren, T Porta, B Balluff - Analyst, 2017 - pubs.rsc.org
Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Mass spectrometry imaging for drug distribution studies

B Prideaux, M Stoeckli - Journal of proteomics, 2012 - Elsevier
Since its introduction mass spectrometry imaging (MSI) has proven to be a powerful tool for
the localization of molecules in biological tissues. In drug discovery and development …

[HTML][HTML] MALDI imaging mass spectrometry: statistical data analysis and current computational challenges

T Alexandrov - BMC bioinformatics, 2012 - Springer
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) imaging mass
spectrometry, also called MALDI-imaging, is a label-free bioanalytical technique used for …

Phospholipids as cancer biomarkers: mass spectrometry‐based analysis

R Bandu, HJ Mok, KP Kim - Mass spectrometry reviews, 2018 - Wiley Online Library
Lipids, particularly phospholipids (PLs), are key components of cellular membrane. PLs play
important and diverse roles in cells such as chemical‐energy storage, cellular signaling, cell …

Optimization and comparison of multiple MALDI matrix application methods for small molecule mass spectrometric imaging

E Gemperline, S Rawson, L Li - Analytical chemistry, 2014 - ACS Publications
The matrix application technique is critical to the success of a matrix-assisted laser
desorption/ionization (MALDI) experiment. This work presents a systematic study aiming to …

Nonuniform distribution of glucosinolates in Arabidopsis thaliana leaves has important consequences for plant defense

R Shroff, F Vergara, A Muck, A Svatoš… - Proceedings of the …, 2008 - National Acad Sciences
The spatial distribution of plant defenses within a leaf may be critical in explaining patterns
of herbivory. The generalist lepidopteran larvae, Helicoverpa armigera (the cotton …