[HTML][HTML] Current status of the diagnosis and management of osteoporosis

A Aibar-Almazán, A Voltes-Martínez… - International journal of …, 2022 - mdpi.com
Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

[HTML][HTML] Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

miRNAs as potential game-changers in bone diseases: Future medicinal and clinical Uses

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

[HTML][HTML] Effects of icariin on modulating gut microbiota and regulating metabolite alterations to prevent bone loss in ovariectomized rat model

S Wang, S Wang, X Wang, Y Xu, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Postmenopausal osteoporosis (PMOP) is an estrogen deficiency-induced bone loss, which
has been shown an association with an altered gut microbiota (GM). Gut microbiota-bone …

Circular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate bone morphogenetic …

R Zhou, S Miao, J Xu, L Sun, Y Chen - Bioengineered, 2021 - Taylor & Francis
This study was designed to study functions of Circ_0000020 during osteogenic
differentiation. First, we used RT-qPCR to detect the expression of Circ_0000020, miR-142 …

New tools for bone health assessment in secreting pituitary adenomas

MM Uygur, S Frara, L di Filippo, A Giustina - Trends in Endocrinology & …, 2023 - cell.com
Pituitary hormones regulate skeletal physiology, and excess levels affect bone remodeling
and alter bone microstructure. Vertebral fractures (VFs) are an early phenomenon of …

[HTML][HTML] Integrative analysis of long non-coding RNAs, messenger RNAs, and MicroRNAs indicates the neurodevelopmental dysfunction in the Hippocampus of gut …

L Liu, H Wang, X Chen, Y Zhang, W Li… - Frontiers in molecular …, 2022 - frontiersin.org
Major depressive disorder is caused by gene–environment interactions and the gut
microbiota plays a pivotal role in the development of depression. However, the underlying …

Osteomyelitis and non-coding RNAS: a new dimension in disease understanding

MS Hussain, NK Shaikh, M Agrawal, M Tufail… - … -Research and Practice, 2024 - Elsevier
Osteomyelitis, a debilitating bone infection, presents considerable clinical challenges due to
its intricate etiology and limited treatment options. Despite strides in surgical and …

[HTML][HTML] CircRNA hsa_circ_0006859 inhibits the osteogenic differentiation of BMSCs and aggravates osteoporosis by targeting miR-642b-5p/miR-483-3p and …

P Yin, Y Xue - International immunopharmacology, 2023 - Elsevier
Hsa_circ_0006859 has been found as a possible biomarker for postmenopausal
osteoporosis (PMOP) with an effect on the osteogenic differentiation of bone marrow …

Role of exosomal MicroRNAs and their crosstalk with oxidative stress in the pathogenesis of osteoporosis

J Lu, Y Zhang, J Liang, J Diao, P Liu… - Oxidative medicine and …, 2021 - Wiley Online Library
Osteoporosis (OP) is an aging‐related disease involving permanent bone tissue atrophy.
Most patients with OP show high levels of oxidative stress (OS), which destroys the …