No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

Atherosclerosis, the leading cause of death worldwide, is responsible for≈ 17.6 million
deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery …

Background The role of complement component 1q (C1Q) related genes on human
atherosclerotic plaques (HAP) is less known. Our aim is to establish C1Q associated hub …

To identify metabolomic reprogramming in early hyperlipidemia, unbiased metabolome was
screened in four tissues from ApoE−/− mice fed with high fat diet (HFD) for 3 weeks. 30, 122 …

Cell membrane phosphatidylcholine (PC) composition is regulated by
lysophosphatidylcholine acyltransferase (LPCAT); changes in membrane PC saturation are …

Atherosclerosis, a highly prevalent cardiovascular disease, has significantly contributed to
morbidity and mortality worldwide. Despite the availability of various treatment options in …

ABCG1 is an essential protein involved in the efflux of intracellular cholesterol to the
extracellular space, thus playing a critical role in reducing cholesterol accumulation in …

Biological membrane-engineered lipid nanoparticles (LNP) have shown enormous potential
as vehicles for drug delivery due to their outstanding biomimetic properties. To make these …

ABCA1 is a key protein in the transport of intracellular cholesterol to the extracellular and
plays an important role in reducing cholesterol accumulation in surrounding tissues …

The vulnerable plaques in atherosclerosis can cause severe outcome with great danger of
acute cardiovascular events. Thus, timely diagnosis and treatment of vulnerable plaques in …