Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic

M Hell, C Bernhofer, P Stalzer… - Beneficial …, 2013 - wageningenacademic.com
In the past two years an enormous amount of molecular, genetic, metabolomic and
mechanistic data on the host-bacterium interaction, a healthy gut microbiota and a possible …

Clostridium difficile in foods and animals: history and measures to reduce exposure

A Rodriguez-Palacios, S Borgmann… - Animal health …, 2013 - cambridge.org
Many articles have summarized the changing epidemiology of Clostridium difficile infections
(CDI) in humans, but the emerging presence of C. difficile in foods and animals and possible …

Hospital-acquired Clostridium difficile infection: determinants for severe disease

JM Wenisch, D Schmid, HW Kuo, E Simons… - European journal of …, 2012 - Springer
Risk factors of severity (need for surgical intervention, intensive care or fatal outcome) were
analysed in hospital-acquired Clostridium difficile infection (CDI) in a 777-bed community …

[HTML][HTML] A review of mixed strain Clostridium difficile colonization and infection

P Dayananda, MH Wilcox - Frontiers in microbiology, 2019 - frontiersin.org
Given that Clostridium difficile is not part of the normal human microbiota, if multiple strains
are to accumulate in the colon implies successive exposure events and/or persistent …

Molecular characterisation of Czech Clostridium difficile isolates collected in 2013–2015

M Krutova, O Nyc, J Matejkova, F Allerberger… - International Journal of …, 2016 - Elsevier
Clostridium difficile is a leading nosocomial pathogen and molecular typing is a crucial part
of monitoring its occurrence and spread. Over a three-year period (2013–2015), clinical C …

Diagnosis of Clostridium difficile: real-time PCR detection of toxin genes in faecal samples is more sensitive compared to toxigenic culture

MBF Jensen, KEP Olsen, XC Nielsen… - European journal of …, 2015 - Springer
The diagnosis of Clostridium difficile infection (CDI) requires the detection of toxigenic C.
difficile or its toxins and a clinical assessment. We evaluated the performance of four nucleic …

Detection of mixed populations of Clostridium difficile from symptomatic patients using capillary-based polymerase chain reaction ribotyping

AA Behroozian, JP Chludzinski, ES Lo… - Infection Control & …, 2013 - cambridge.org
Objective. To investigate the simultaneous occurrence of more than 1 Clostridium difficile
ribotype in patients' stool samples at the time of diagnostic testing. Methods. Stool samples …

Capillary electrophoresis based on nucleic acid detection for diagnosing human infectious disease

DS Lian, SJ Zhao - Clinical Chemistry and Laboratory Medicine …, 2016 - degruyter.com
Rapid transmission, high morbidity, and mortality are the features of human infectious
diseases caused by microorganisms, such as bacteria, fungi, and viruses. These diseases …

Prevalence of binary toxin positive Clostridium difficile in diarrhoeal humans in the absence of epidemic ribotype 027

AM McGovern, GO Androga, DR Knight, MW Watson… - PLoS …, 2017 - journals.plos.org
Virulence of Clostridium difficile is primarily attributed to the large clostridial toxins A and B
while the role of binary toxin (CDT) remains unclear. The prevalence of human strains of C …

Patience is a virtue: an argument for delayed surgical intervention in fulminant Clostridium difficile colitis

J Clanton, R Fawley, N Haller, T Daley… - The American …, 2014 - journals.sagepub.com
Recently, the incidence and severity of Clostridium difficile infection (CDI) has increased. In
cases of fulminant infection, surgery is a viable therapeutic option but associated with high …